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1、ORGANICLETTERSHighlyEfficientOne-Pot2006Vol.8,No.10Three-ComponentMannichReactionin2079-2082WaterCatalyzedbyHeteropolyAcidsNajmodinAzizi,LallehTorkiyan,andMohammadR.Saidi*DepartmentofChemistry,SharifUniVersityofTechnology,P.O.Box11465-9516,Tehran11365,Iransaidi@
2、sharif.eduReceivedFebruary28,2006ABSTRACTHeteropolyacidsefficientlycatalyzedtheone-pot,three-componentMannichreactionofketoneswitharomaticaldehydesanddifferentaminesinwateratambienttemperatureandaffordedthecorrespondingâ÷-aminocarbonylcompoundsingoodtoexcellenty
3、ieldsandwithmoderatediastereoselectivity.Thismethodprovidesanovelandimprovedmodificationofthethree-componentMannichreactionintermsofmildreactionconditionsandcleanreactionprofiles,usingveryasmallquantityofcatalystandasimpleworkupprocedure.Carryingoutorganicreacti
4、onsinwaterhasbecomehighlyprovideâ-aminocarbonylcompounds,whichareimportantdesirableinrecentyearstomeetenvironmentalconsider-syntheticintermediatesforvariouspharmaceuticalsandations.1Theuseofwaterasasolemediumfororganicnaturalproducts.4Theincreasingpopularityofth
5、eMannichreactionswouldgreatlycontributetothedevelopmentofreactionhasbeenfueledbytheubiquitousnatureofnitrogen-environmentallyfriendlyprocesses.Indeed,industrypreferscontainingcompoundsindrugsandnaturalproducts.5tousewaterasasolventratherthantoxicorganicsolvents.
6、However,theclassicalMannichreactionisplaguedbyaInthiscontext,inrecentyears,muchattentionhasbeennumberofseriousdisadvantagesandhaslimitedapplications.focusedonLewisacidcatalyzedorganicreactionsinwater.Therefore,numerousmodernversionsoftheMannichHeteropolyacids(HP
7、As)areenvironmentallybenignandreactionhavebeendevelopedtoovercomethedrawbackseconomicallyfeasiblesolidcatalyststhatofferseveraloftheclassicalmethod.Ingeneral,theimprovedmethodol-advantages.2Therefore,organicreactionsthatexploithet-ogyreliesonthetwo-componentsyst
8、emusingpreformederopolyacidcatalystsinwatercouldproveidealforindustrialelectrophiles,suchasimines,andstablenucleophiles,suchsyntheticorganicchemistryapplications,prov
