血液灌流对有机磷和混配农药与阿托品清除作用的实验分析

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1、山东大学硕士学位论文HA230树脂作吸附剂，则剂量选择1．59，灌流1．5h较适宜。在混配农药中毒灌流吸附时，用1．59包膜活性炭灌流2．0h或1．59ilA230树脂灌流1．0h较适宜。在灌流刚开始的一段时间阿托品的补用量占总体补用量的比例宜加大，但整个灌流过程中总体补用量要较传统治疗小。总的来说m也30树脂对有机磷农药的吸附能力要优于包膜活性炭，但对ATP的吸附能力也同样强于包膜活性炭，因此采用HA230树脂灌流时更要严密监视ATP用量。关键词血液灌流；有机磷农药：阿托品；色谱检测：清除速率3山东大学硕士学位论文EMPIRICALSTUDYONADSORPTIONEFF

2、ECTOFOPSANDⅣⅡXEDPESTICIDESANDATRoPINEINHEMOPERFUSIONGraduateJinYonKiiuTutorProfessorChenYanjunABSTRACTobiectiveItshowsthedisadvantagesofI-IPasanewtherapyOilOPspoisoningpatientsthatHPsimultaneouslyadsorbsOPsandAtropineforbadselectivityofadsorbens．Therefore，itisnoteasytOdecidethedosageofAtro

3、pine，whichleadstOinsufficiencyofatropineoratropinepoisoning．SowetriedtOmonitorconcentrationofOPsandmixedpesticidesandAtropineinbloodbyimitated眦evaluatedcleaningvelocityofOPsandmixedpesticidesandAtropine，andexploredsuitabledosageofadsorbentandthesupplementaryruleofAtropineinI-IP．MethodPurif

4、icationanddetectionofOPsandK喂inblood：WeextractedtheOPsinbloodbyusingaceticetheranddetectedthembvGC—FPD．WeprecipitatedproteininbloodwithO．05mol‘L一1perchloricacid．thencentrifugalizedbloodsample．extractedATPfromsupematantanddetectedATPbyHPLC州detector．ImitatingclinicalHP：Imitatingequipmentofcl

5、inicalHPwithHA230resinandMMACinlaboratory,werespectivelytOokOPsandmixedpesticidesandK时throughimitatedextracorporealclosedcirculatingperfusionapparatus，andthenOPsweredetectedbyGCandAtropineWasdetectedbyHPLC．ThentheclearancevelocityofOPsandmixedpesticidesandAtropineWasacquiredaccordingtothec

6、orrespondingtheirvestigialconcentration．Result4山东大学硕士学位论文AdsorptiontoCadusafosinHP：ConcentrationofCadusafosinbloodbeforeHPwas9．9999／ml，afterHPtheconcentrationofCadusafosquicklydescended．DuringthesameperiodofHP,concentrationofCadusafosinbloodincreasingdecreasedbyO．59Group，1．09Group，1．59Grou

7、p；Forthesamedosageofadsorbens，concentrationofCadusafosinbloodinHPwithHA230resinwaslessthanwithMMACin2．Oh．But,thechangeofconcentrationofCadusafoswaslessandless"obviouswhenlengtheningthetimeofHPwithMMACorHA230resin，andwouldshowupaplatformperiodandbeabout1．5h~2．O