基于生物粘附分子表面改性的组织修复材料的-研究

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1、4．对于多巴胺改性前后的PAGP材料通过与PUA材料进行对比，对这四种静电纺丝膜材料进行细胞培养，研究这四种材料的生物学特性，初步进行了细胞生物学评价；5．采用多巴胺改性的方法，对于应用于齿科方向的纤维增强树脂基复合材料进行多巴胺改性，期望改善其界面的粘接性，并对改性前后的材料进行材料学表征；6．通过拔出力测试，对多巴胺改性前后的纤维增强树脂基复合材料统计拔脱形式，统计拔脱力的最大数值，初步对其完成了力学性能的研究。7．对多巴胺改性有机物表面的原理进行了初步的探索，为多巴胺改性原理的进一步研究提供了依据。关键词：

2、多巴胺，聚膦腈，骨修复，纤维增强树脂基复合材料IIABSTRACTBASEDoNBIoLoGICALADHESIoNMoLECULARSURR～CEMoDIFICATIoNoFTISSUEREPAIRM【ATERIALSRESEARCHPoly(dopamine)coatingisapotentialtechniqueformodification．Dopamineisakindofmusseladhesionprotein，whichcontainsrichethylaminoandcatechins，whic

3、hcanbeemployedtomodifymostsurfaceofmaterials，especiallyfororganicmaterials．Theusingofpoly(dopamine)coatingwaswidelyacceptedintheareaoftissueengineeringforthecoatingprocedureismild，solvent—free，non-toxicandtime—saving．Thepoly(dopamine)coatingwouldnotcauseadver

4、seeffectsonThephysio—chemicalpropertiesofbiodegradablepolymersandthe3Dporousstructureofthescaffold．Inthisstudy,poly(dopamine)coatingwasintroducedtoimprovetheadhesionandbiocompatibilityofthescaffoldmaterialsusedfortissueengineering．Mainworkasfollow：Thelinearpo

5、lyphosphazenewassynthetizedviaring-openingpolymerization，andthesynthesisparameters，suchastemperature，time，etc．，wereoptimized；(1)ThenanofibrousmembraneswerefabricatedbyusingofllI北京化T人学硕I二学位论文electrospinningtechnique，andthefabricationparameters，suchasvoltage，fl

6、owrate，temperature，etc．，wereoptimized；(2)Thesurfacemodifiedelectrospunnanofibrousmaterialswerepreparesviatheoxidizationpolymefizationofdopamineinaqueoussolutionatasuitablecondition，andtheeffectsofmodificationwerecharacterized；(3)Thebiologicalperformanceofelec

7、trospunnanofibrousmembranesmodifiedbypoly(dopamine)wasdetectedbyevaluationofthecellattachment，proliferationanddifferentiation；(4)Thepolydopaminesurfacemodifiedglassfiberpostswerepreparedandcharacterized；(5)Pull—outtestswereemployed，andthemaximumfailureload(N)

8、andthefailuremodeswereevaluatedtodetecttheinterfacialadhesionbetweenfiberpostandresincore；(6)themechanismofpoly(dopamine)modificationontheorganicmaterialswaspreliminarilystudied．KEYWORDS：