抗肾小球基底膜抗体相关疾病的临床特点分析

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1、山东大学硕士学位论文。ACLINICALANALYSiS0FPATIENTSWITHANTI．GLoMERULARBASEMENTMEMBRANEANTIBoDYRELATEDDISEASESPostgraduate：YuHainaTutor：Prof．WangRongAbstractobjectiveToinvestigatetheclinicalandpathologicalcharacteristicsofanti—glomerularbasementmembrane(GBM)antibodyassociateddiseaseswithdifferentclinicalpaRerns

2、，andtodeepenthecomprehensionofthediseasesandraisetheearlydiagnosisandcurerate．MethodsTheclinicalandpathologicaldataof22patientswimanti-GBMantibodyassociateddiseasesdiagnosedinrenalinstituteofShandongProvincialHospitalinthelastfiveyears，wereretrospectivelyanalyzed．Results1．Theseveritiesofdiseasesof

3、22patientsweredifferent．21patientsweremanifested嬲acutenephritissyndromewithrapidlyprogressiverenalfailureandanima,lpatientwithnormalrenalfunctions，8Caseswithpneumorrhagia．2．Ofthe22patients，11oneshadpositiveanti-GBMantibodyonly,7oneshadbothanti—GBMantibodyandantineutrophilcytoplasmicantibody(ANCA)p

4、ositive，and4oneshadbothanti-GBMantibodyandanti—nuclearantibody(ANA)positive．Inthetbirdgroup，onepatienthadanti-double—strand-DNA(ds—DNA)antibodypositive，meanwhile，anotherwimbothanti-ds-DNAantibodyandanti-Smith(Sm)antibodypositive．Inthegroupofbothanti—GBMantibodyandANCApositive，theaverageagewasolder

5、andtheaveragelevelofanti—GBMantibodyWaslowerthantheothertwogroups，butthereWas．nostatisticalsignificance．Therewerealsonosignificant3山东大学硕士学位论文differencesattheeffmiencyoftreatmentamongthethreegroups．3．1lofthe13patientswithrenalbiopSyhadcrescenticglomerulonephritis，6ofwhomhadmorethan85％ofglomerliaffe

6、ctedbycrescents．Astotheremaining2patients，onepresented谢也chronicsclerosingglomerulonephritis，andtheotherWaS谢mmildmesangialproliferativeglomerulonephritis．Withilnrnunofluoreseeneeexaminations，noneofthe13patientshadtypicalIgGandC3lineardepositionalongglomerularcapillarywalls．8patientshadimmunoglobuli

7、nsand／orcomplementsgranuladepositionalongglomerularcapillarywallsandinmesangium，and3oneswerewimnegativeimmunoinfluorescence．4．Therewerenosignificantdifferencesatthelevelofanti-GBMantibodyatthetimeofdefinitediagno