p53、pcna、vegf在膀胱尿路上皮癌中的表达及对预后的影响

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1、中图分类号：R737.14编号：20090131承德医学院硕士研究生毕业论文P53、PCNA、VEGF在膀胱尿路上皮癌中的表达及对预后的影响Thecorrelationofp53、PCNAandVEGFproteinexpressionwithtumorprognosisinurothelialcarcinomaofbladder研究生：王泽民导师：于满教授、主任医师学科专业：肿瘤学所在系部：承德医学院附属医院研究起止日期：2009年9月~2012年3月论文提交日期：2012年3月承德医学院学位论文使用授权及知识产权归属承诺本学位论文在导师（或指导小组）的指导下，由本人独立

2、完成。本学位论文研究所获的研究成果，其知识产权归承德医学院所有。承德医学院有权对本学位论文进行交流、公开和使用。凡发表与学位论文主要内容相关的论文，第一署名单位为承德医学院，试验材料、原始数据、申报的专利等知识产权均归承德医学院所有。否则，承担相应的法律责任。研究生签名：导师签章：年月日承德医学院研究生学位论文独创性声明本论文是在导师指导下进行的研究工作及取得的研究成果，除了文中特别加以标注和致谢等内容外，文中不包含其他人已经发表或撰写的研究成果，指导教师对此进行了审定。本论文由本人独立撰写，文责自负。研究生签名：导师签章：年月日P53、PCNA、VEGF在膀胱尿路上皮癌中

3、的表达及对预后的影响Thecorrelationofp53、PCNAandVEGFproteinexpressionwithtumorprognosisinurothelialcarcinomaofbladder研究生：王泽民学号：20090131年级：2009级导师：于满教授、主任医师学科专业：肿瘤学所在系部：承德医学院附属医院研究方向：泌尿系肿瘤的诊治研究起止日期：2009年9月~2012年3月论文提交日期：2012年3月目录中文摘要··································································1英文

4、摘要··································································4英文缩写··································································8研究论文P53、PCNA、VEGF在膀胱尿路上皮癌中的表达及对预后的影响前言··································································9材料与方法········································

5、··················9结果··································································13附图··································································16附表··································································27讨论···························································

6、·······31结论··································································38参考文献·····························································39综述··································································42致谢··································································52个人简历

7、··································································53中文摘要P53、PCNA、VEGF在膀胱尿路上皮癌中的表达及对预后的影响摘要膀胱癌居我国泌尿系统肿瘤发病率的首位，近年来有递增趋势。手术治疗是膀胱癌的主要治疗方式(主要包括经尿道膀胱肿瘤电切术、膀胱部分切除术和根治性全膀胱切除术)，同时术后给予辅助化疗以及免疫治疗等，临床效果较好，但术后肿瘤复发率高给临床带来挑战。临床中缺少敏感而特异的膀胱肿瘤预后指标，从分子及基因水平研究影响膀胱