盐酸戊乙奎醚预防腰麻—硬膜外联合阻滞麻醉下妇科手术患者术后恶心呕吐的效果

《盐酸戊乙奎醚预防腰麻—硬膜外联合阻滞麻醉下妇科手术患者术后恶心呕吐的效果》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、青岛大学硕士学位论文盐酸戊乙奎醚预防腰麻--硬膜外联合阻滞麻醉下妇科手术患者术后恶心呕吐的效果姓名：张珂申请学位级别：硕士专业：麻醉学指导教师：殷积慧20120602盐酸戊乙奎醚预防腰麻一硬膜外联合阻滞麻醉下妇科手术患者术后恶心呕吐的效果摘要目的抗胆碱类药是常用的抗呕吐药，本研究是观察抗胆碱类药盐酸戊乙奎醚用于腰麻一硬膜外联合阻滞麻醉下子宫切除术后恶心呕吐的防治效果及副作用。资料与方法选择腰麻一硬膜外联合阻滞麻醉下择期行子宫切除术患者120例，ASAI～II级，随机分为盐酸戊乙奎醚组(W组)、托烷司琼组(T组)和生理盐水组(C组)三组，每组40例。每组患者经L：一。行腰

2、麻一硬膜外联合阻滞麻醉操作成功后，注入0．75％罗哌卡因1．9mI+50％GSO．Iml腰麻液，术中静脉辅助药为布托啡诺，术中不应用其他镇静镇痛药以及止吐药物。手术结束时分组静脉注射盐酸戊乙奎醚0．5mg、托烷司琼5mg和生理盐水5ml。观察各组术后6、12、24h内恶心呕吐分级、口于评分、术后Ramsay镇静评分及术后其它副作用(头晕、尿潴留、复视、谵妄)发生情况。结果W组、T组术后6-24h恶心呕吐的发生率显著低于C组(P

3、生无统计学差异(P>O．05)。结论盐酸戊乙奎醚0．5mg对于腰麻一硬膜外联合阻滞麻醉下子宫切除术患者术后恶心呕吐有较好防治作用，且具有适度中枢镇静作用。硕士研究生张珂(麻醉学)指导教师殷积慧教授关键词：盐酸戊乙奎醚；术后恶心呕吐；腰麻一硬膜外联合阻滞麻醉；子宫切除术；托烷司琼Preventiveeffectofpenehyclidinehydrochlorideonpostoperativenauseaandvometinginpatientswithgynecologicaloperationaftercombinedspina—epiduralanesthesia

4、AbstractobjectiveAnticholinergicdrugsiSoftentobeusedaspreventivedrugsonpostoperativenauseaandvomcting(PC}NV)．ThepurposeofpresentstudyiStOinvestigatethepreventiveeffectandsideeffectsofpenehyclidinehydrochlorideonpostoperativenauseaandvometinginhysterectomyaftercombinedspina．epiduralanesth

5、esia．MethodsOnehundredandtwentypatients(ASAphysicalstatusIorII1scheduledforselectivehysterectomyundercombinedspina-epiduralanesthesiawererandomlydividedinto3groups谢th40caseseach：groupW，groupTandgroupCinthisstudy．ThesepatientsreceiveddrugsofO．75％ropivacaine1．9mland50％GSO．1mlaftersuccessfu

6、lcombinedspina-epiduralanesthesiaattheL2．3interspace．Allpatientsreceivednootherdrugsbutbutorphanolduringtheanesthesia．Attheendofsurgery。groupWWasgivenpenehyclidinehydrochlorideO．5mg．groupTtropisetron5mgandgroupCnormalsaline5mlbyintravenousinjection．，nlescoreofPONVandthirstat6，l2，24h，seda

7、tionscore(Ramsay)andincidenceofothersideeffects(suchasdizziness．urinaryretention，diplopiaanddelirium)afteroperationwererecorded．ResultsDuringthetimefromthe6thhoursto24thafteroperation．PoNVscoreinGroupWandGroupTwaslowerthanthatinGroupC(P<0．05)：Duringthetimefromthe0hoursto6