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1、提要目的:观察左金泻心汤加减治疗寒热错杂型胆汁反流性胃炎的临床疗效,并初步探讨其作用机理。方法:选择符合纳入标准的寒热错杂型胆汁反流性胃炎患者60例,随机分为两组,试验组(30例)给予左金泻心汤,水煎至400mL,早晚各温服200mL,日一剂;对照组(30例)给予胃力康颗粒口服,日3次,每次1包。观察两组的临床疗效。结果:左金泻心汤加减能明显改善患者的临床症状,疗效显示:试验组总有效率为96.67%,对照组的总有效率为80.00%,两组疗效经秩和检验,P<0.05,试验组疗效优于对照组;胃镜下疗效:试验组总有效率为93.33%,对照组总有效率为76.67%,两组疗效经秩和检验,P<
2、0.05,试验组疗效优于对照组。结论:左金泻心汤加减与胃力康颗粒对寒热错杂型胆汁反流性胃炎均有较好疗效,且左金泻心汤疗效优于胃力康颗粒,值得进一步研究及推广。关键词胆汁反流性胃炎;寒热错杂;左金泻心汤加减;临床研究ClinicalStudyofModifiedZuojinxiexintangintheTreatmentofCoIdandheatmixedtypeofBRGSpeciality:InternalMedicineofTCMAuthor:ZhangShujuanTutor:Prof.WangWeimingAbstractObjectives:Observationofef
3、fectsofZuojinXiexinDecoctioninthetreatmentofthecold-heatjumbleofbilerefluxgastritisclinicalefficacy,andtoexploreitsmechanism.Methods:ZuojinXiexinDecoctioncouldobviouslyimprovetheclinicalsymptomsofthepatients,theefficacyofdisplay:experimentalgrouptotaleffectiveratewas96.67%,comparedtothecontrol
4、groupinthetotalefficiencywas80%,theeffectoftwogroupsbyranksumtest,P<0.05,thetestgroupwasmoreeffectivethanthecontrolgroup.Undertheeffectofgastroscopy:experimentalgrouptotaleffectiveratewas93.33%,totaleffectiveratewas76.67%incontrolgroup,twogroupsofefficacybyranksumtest,P<0.05,experimentalgroupi
5、sbetterthanthatofcontrolgroup.Results:ZuojinXiexinDecoctioncouldobviouslyimprovetheclinicalsymptomsofthepatients,clinicalsymptoms:controlgroup,thetotalefficiencyof96.67%fortheexperimentalgroup,thetotalefficiencyof80%,twogroupsoftheranksumtest,P<0.05,thetestgroupwasmoreeffectivethanthecontrolgr
6、oup;undertheeffectofgastroscopy:controlgroup,thetotalefficiencyof93.33%thetestgroup,thetotalefficiencyof76.67%,twogroupsoftheranksumtest,P<0.05,experimentalgroupisbetterthanthatofcontrolgroup.Conclusion:ZuojinXiexinDecoctionandWeilikangparticlesonthecold-heatjumbleofbilerefluxgastritishasgoodc
7、urativeeffect,andZuojinXiexinDecoctioncurativeeffectisbetterthanthatofWeilikang,worthyoffurtherresearchandpromotion.KeywordsBilerefluxgastritis;cold-heatjumble;ZuojinXiexinDecoction;clinicalresearch目录引言..................................