麝香四黄汤治疗痰热腑实型急性脑梗死的临床研究

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1、提要目的：观察麝香四黄汤治疗痰热腑实型急性脑梗死的临床疗效及安全性，并探讨其作用机理。方法：本研究受试对象均取自2010年11月至2011年10月山东省潍坊市中医院中风科住院患者。将60例入选痰热腑实型急性脑梗死患者按入院先后顺序随机分为对照组与治疗组各30例，对照组采用常规治疗，治疗组在常规治疗基础上加用麝香四黄汤。观察两组的临床疗效及实验室观察指标的变化，同时在治疗期间密切观察不良反应。结果：治疗组综合疗效、中医症侯疗效优于对照组（P＜0.05）。治疗后治疗组神经功能缺损评分、中医症候积分积分均明显降低，与对照组比较，有显著性差异（

2、P＜0.01）。治疗后两组血浆同型半胱氨酸（Hcy）、高敏C反应蛋白（hs-CRP）、纤维蛋白原（FIB）及D-二聚体（D-D）水平均明显降低（P＜0.01），治疗组优于对照组，有显著性差异（P＜0.05）。治疗组治疗期间未发生不良反应，对照组不良反应发生率为6.67%。结论：麝香四黄汤治疗痰热腑实型急性脑梗死疗效显著，安全可靠，有进一步研究推广的价值。关键词急性脑梗死；痰热腑实型；麝香四黄汤；临床研究。TheClinicalResearchontheTreatmentofPhlegm-HeatAccumulationofAcuteCe

3、rebralInfarctionbyShexiang-SihuangDecoctionSpecialty:Neurology.InternalmedicineofTCMAuthor:ZhangHuanxinTutor:Prof.ZhangLunzhongAbstractObjective:Toobservetheeffectandthesafetyofshexiang-sihuangdecoctiononthephlegm–HeatAccumulationofacutecerebralinfarctionandexplorethemec

4、hanismofit.Methods:ThestudysubjectsweretakenfromthepatientswhoadmissedintheNeurologyofWeiFangtraditionalmedicineHospitalduringthetimefromNovember2010toOctober2011.60caseswithPhlegm-HeatAccumulationofAcuteCerebralInfarctionwererandomlydividedintotheexperimentalgroupandthe

5、controlgroup.Thecontrolgroupwasgivenconventionaltreatementer,whiletheexperimentalgroupwasgivenshexiang-sihuangdecoctioncombinedwithconventionaltreatement.Theclinicaleffectsandthelaboratoryindicatorsofeachgroupewereobserved.Atthesametime,closelyobservetheadversereactionsd

6、uringthetimeoftakingmedication.Observetheclinicalefficacyandthechangesofthelaboratoryindicatorsofthetwogroups,whilecloselyobservetheadversereactionsduringthetreatment.Results:theoverallclinicaleffectandtheeffectoftheTraditionalChinesemedicinesyndromeoftheexperimentalgrou

7、pissuperiortothecontrolgroup(P＜0.05).theNeuralfunctiondefectscoreandthechinesemedicinesymptomscoresoftheexperimentalgroupweresignificantlyreduced,comparedwiththecontrolgroup,therewassignificantdifference(P＜0.01).Hcy,hs-CRP,FIBandD-Dofthetwogroupsweresignificantlyreduced(

8、P＜0.01).Theexperimentalgroupwassuperiortothecontrolgroup(P＜0.05).Therewasnoadversereactionhappenedinthe