肝气虚失眠症机理探讨及大补肝汤临床疗效观察

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1、提要目的：通过对肝气虚型失眠症的病因病机探讨及大补肝汤的临床疗效观察，验证大补肝汤治疗失眠症的临床适用性。方法：本研究从临床上选择符合纳入标准的肝气虚型失眠症患者60例，随机分为两组，即治疗组（大补肝汤组）30例，对照组（甜梦胶囊组）30例，分别给予相应药物进行临床治疗，疗程均为3周。观察患者治疗前后PSQI量表、中医症候评分的变化。结果：经过统计学分析，治疗前两组在一般资料包括年龄、性别、PSQI积分、中医症候评分等方面无明显统计学差异，具有可比性。治疗后两组均较前有所改善，但治疗组在改善中医症候方面优于对照组。1.按照《中药新药临床研究指导原则》标准评价的临床疗效比较，治疗组总有效率为9

2、3.33%,对照组总有效率为73.33%，两组临床疗效之间有显著性差异（PC0.01)。2.按照PSQI改善率评价疗效比较，治疗组愈显率63.33%，总有效率90%;对照组愈显率20.00%，总有效率76.67%，两组疗效比较差异有统计学意义（尸<0.05)。3.在PSQI总分及各成分积分比较方面，两组总体疗效比较差异有统计学意义，治疗组优于对照组（P<0.05)。结论：大补肝汤具有良好的镇静安神作用，能有效改善患者的失眠症状，对四肢倦怠、恐疑不安、脘痞胁痛等伴随症状也有明显的疗效，证明大补肝汤组方严谨科学，治疗肝气虚型失眠症具有较好的临床疗效。关键词失眠症；肝气虚；大补肝汤；临床观察Liv

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4、omnia.Methods:ChoosefromaclinicalstudymettheinclusioncriteriaoftheLiverQiDeficiency60patientswererandomlydividedintotwogroups,namelythetreatmentgroup30patientsinthecontrolgroup30cases,respectively,giventheappropriatedrugforclinicaltreatmentcourseof3weeks.BeforeandaftertreatmentPSQIscale,clinicalsym

5、ptomsscorechanges.Results:Afterstatisticalanalysis,beforetreatmentinthegeneralinformationincludingage,gender,PSQIpointsandsonosignificantdifference,comparable.Aftertreatmenthasimprovedthanbefore,butthetreatmentgroupinimprovingsymptomsintraditionalChinesemedicinethanthecontrolgroup.1.Accordingto"Chi

6、neseherbalmedicineclinicalresearchguidingprincipleoftheclinicalcurativeeffectofstandardevaluationcomparison,thetotaleffectiverateofthetreatmentgroupandcontrolgrouptotaleffectivenessis93.33%、73.33%,betweentwogroupsofclinicalcurativeeffectwassignificantdifference(p<0.01).2.ComparePSQIperiodinaccordan

7、cewith,andthetherapeuticevaluationandgreater63.33%,withthetotaleffectiverateof90%;Thecontrolgroup,thetotaleffectiverateofexplicit20.00%、76.67%;Twogroupswasstatisticallysignificanteffectcomparativedifference