儿童eb病毒感染相关im和hlh的临床分析和病毒感染特征

《儿童eb病毒感染相关im和hlh的临床分析和病毒感染特征》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、广州医学院硕士学位论文儿童EB病毒感染相关IM和HLH的临床分析和病毒感染特征ClinicalresearchandVirologicalFeaturesofEpstein-BarrVirusAssociatedInfectiousMononucleosisandHemophagocyticLymphohistiocytosis专业名称：儿科学硕士研究生：陶佳导师：赖永洪教授陈福雄教授广州医学院·广州2012年5月目录主要英文缩略词表„„„„„„„„„„„„„„„„„„„1中文摘要„„„„„„„„„„„„„„„„„„„„„„„2英文摘要

2、„„„„„„„„„„„„„„„„„„„„„„„8前言„„„„„„„„„„„„„„„„„„„„„„„„14第一部分EBV感染患儿临床及实验室检查特点分析„„„„181.研究对象和方法„„„„„„„„„„„„„„„„„182.结果„„„„„„„„„„„„„„„„„„„„„„203.讨论„„„„„„„„„„„„„„„„„„„„„„214.结论„„„„„„„„„„„„„„„„„„„„„„25第二部分EBV感染患儿血清学抗体检测与临床关系分析„„261.材料和方法„„„„„„„„„„„„„„„„„„„272.结果„„„„„„„„„„„„„„„„„

3、„„„„„293.讨论„„„„„„„„„„„„„„„„„„„„„„314.结论„„„„„„„„„„„„„„„„„„„„„„32第三部分EBV感染患儿血清EBV-DNA负载量检测分析„„„„331.材料与方法„„„„„„„„„„„„„„„„„„„332.结果„„„„„„„„„„„„„„„„„„„„„„363.讨论„„„„„„„„„„„„„„„„„„„„„„394.结论„„„„„„„„„„„„„„„„„„„„„„41全文结论„„„„„„„„„„„„„„„„„„„„„„42附表附图„„„„„„„„„„„„„„„„„„„„„„43参考文献„„„

4、„„„„„„„„„„„„„„„„„„„46综述„„„„„„„„„„„„„„„„„„„„„„51攻读学位期间公开发表的论文„„„„„„„„„„„„„64致谢„„„„„„„„„„„„„„„„„„„„„„65学位论文原创性声明„„„„„„„„„„„„„„„„„66学文论文知识产权权属声明„„„„„„„„„„„„„„66关于学位论文使用授权的说明„„„„„„„„„„„„„66EB病毒感染相关IM和HLH的临床研究和病毒感染特征主要英文缩略词表Abbreviation缩略词英文全称中文ALTAlanineaminotransferase丙氨酸氨基

5、转移酶ASTAspartateaminotransferase天门冬氨酸氨基转移酶EAEarlyantigen早期抗原EBVEpstein-BarrVirusEB病毒EBV-AHSEpstein-Barrvirus-associatedHemophagocyticEB病毒相关性噬血淋lymphohistiocytosis巴组织细胞增生症EBNAEpsteinbarrvirusnuclearantigenEBV核抗原FQ-PCRFluorescencequantitativepolumerasechainreaction荧光定量聚合酶链反

6、应FHLHFamilialhemophagocyticlymphohistiocytosis家族性噬血淋巴组织细胞增生症HLHHemophagocyticlymphohistiocytosis噬血性淋巴组织细胞增生症IAHSVirus-associatedhemophagocyticsyndrome病毒相关性噬血细胞综合征IMInfectiousmononuucleosis传染性单核细胞增多症MAMembraneantigen膜抗原PCRPolumerasechainreaction聚合酶链反应PTLDPosttransplantlym

7、phoproliferativedisords移植后淋巴细胞增殖性疾病SLAMSignallymphocyteactivationmolecule信号淋巴细胞活化分子SAPSignallymphocyteactivationmolecule(SLAM)-信号淋巴细胞活化分子-associatedprotein相关蛋白VCAViralcapsidantige病毒衣壳抗原1EB病毒感染相关IM和HLH的临床研究和病毒感染特征儿童EB病毒感染相关IM和HLH的临床研究和病毒感染特征硕士研究生：陶佳导师：赖永洪教授陈福雄教授广州医学院第一附属医

8、院儿科中文摘要研究背景：EB病毒（Epstein-Barr，EBV）为双链DNA病毒，是一种嗜人B淋巴细胞病毒，属于疱疹病毒γ亚科家族中的一员。该病毒在人群中普遍易感，国外报道，[1]成人血清EBV抗体阳性