【5A文】知名三甲医院之丙肝医学知识课程.ppt

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1、【5A文】知名三甲医院之丙肝医学知识课程主要内容2123BMS丙肝研发历程中国丙肝研究数据HCV常见问题AI447-036studyHCVSocsurveyCCgenosstudy干扰素为基础的治疗DAA+P/R全口服DAA治疗20余年来丙肝治疗的演变2011~2014~疗效SVR在不断提高疗程疗程在不断缩短服用注射到全口服1991~Non-structuralprotein5AEssentialforHCVviralreplicationModulatesvirionmorphogenesisFirsttotar

2、getNS5A1,2NS34BNS5BNS5A198920102011201220132014+DAA=direct-actingantiviral;PegIFN=pegylatedinterferon;DCV=daclatasvir;ASV=asunaprevir;RBV=ribavirin;SOV=sofosbuvir;SVR12=sustainedvirologicresponse12weekspost-treatment;SVR24=sustainedvirologicresponse24weekspost

3、-treatment;SVR4=sustainedvirologicresponse4weekspost-treatment.1.ChooQl,etal.Science.1989;244(4902):359-362.2.TellinghuisenTL,etal.Nature.2005;435(7040):374-379.4.FreemanJA,etal.Hepatology.201052SUPPL.1(721A).BMS丙肝研发里程碑事件Potent,specificNS5AinhibitorInhibitsmul

4、tiplestagesofviralRNAreplicationPangenotypicefficacyDiscoveryofdaclatasvir:potentsmallmoleculeNS5Ainhibitor3198920102011201220132014+DAA=direct-actingantiviral;PegIFN=pegylatedinterferon;DCV=daclatasvir;ASV=asunaprevir;RBV=ribavirin;SOV=sofosbuvir;SVR12=sustai

5、nedvirologicresponse12weekspost-treatment;SVR24=sustainedvirologicresponse24weekspost-treatment;SVR4=sustainedvirologicresponse4weekspost-treatment.3.GaoM,etal.Nature.2010;465(7294):96-100.BMS丙肝研发里程碑事件Addingdaclatasvir+asunaprevir(NS3/4proteaseinhibitor)toPegI

6、FN/RBVimprovedSVR24GT1nullrespondersFirsttodemonstratethatdualDAAscanenhancetheefficacyofPegIFN/RBVregimen4198920102011201220132014+DAA=direct-actingantiviral;PegIFN=pegylatedinterferon;DCV=daclatasvir;ASV=asunaprevir;RBV=ribavirin;SOV=sofosbuvir;SVR12=sustain

7、edvirologicresponse12weekspost-treatment;SVR24=sustainedvirologicresponse24weekspost-treatment;SVR4=sustainedvirologicresponse4weekspost-treatment.1.ChooQl,etal.Science.1989;244(4902):359-362.2.TellinghuisenTL,etal.Nature.2005;435(7040):374-379.3.GaoM,etal.Nat

8、ure.2010;465(7294):96-100.4.FreemanJA,etal.Hepatology.201052SUPPL.1(721A).DAA=direct-actingantiviral;PegIFN=pegylatedinterferon;DCV=daclatasvir;ASV=asunaprevir;RBV=ribavirin;SOV=so