纳米电化学生物传感器

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1、第21卷第1期化学进展Vol.21No.12009年1月PROGRESSINCHEMISTRYJan.,20093纳米电化学生物传感器33杨海朋陈仕国李春辉陈东成戈早川(深圳大学材料学院深圳市特种功能材料重点实验室深圳518060)摘要纳米电化学生物传感器是将纳米材料作为一种新型的生物传感介质,与特异性分子识别物质如酶、抗原P抗体、DNA等相结合,并以电化学信号为检测信号的分析器件。本文简要介绍了生物传感器的分类和纳米材料在电化学生物传感器中的应用及其优势,综述了近年来各类纳米电化学生物传感器在生物检测方面的研究进展,包

2、括纳米颗粒生物传感器,纳米管、纳米棒、纳米纤维与纳米线生物传感器,以及纳米片与纳米阵列生物传感器等。关键词生物传感器电化学传感器纳米材料生物活性物质固定化中图分类号:O65711;TP21213文献标识码:A文章编号:10052281X(2009)0120210207NanomaterialsBasedElectrochemicalBiosensors33YangHaipengChenShiguoLiChunhuiChenDongchengGeZaochuan(ShenzhenKeyLaboratoryofSpecial

3、FunctionalMaterials,CollegeofMaterialsScienceandEngineering,ShenzhenUniversity,Shenzhen518060,China)AbstractBiosensorswhichutilizeimmobilizedbioactivecompounds(suchasenzymes,antigen,antibody,DNA,etc.)fortheconversionofthetargetanalytesintoelectrochemicallydetecta

4、bleproductsisoneofthemostwidelyuseddetectionmethodsandhavebecomeanareaofwiderangingresearchactivity.Theadvancesinbiocompatiblenanotechnologymakeitpossibletodevelopnewbiosensors.Avarietyofbiosensorswithhighsensitivityandexcellentreproducibilitybasedonnanotechnolog

5、yhavebeenreportedinrecentyears.Inthispaper,thedevelopmentoftheresearchesonnanoamperometricbiosensors,oneofthemostimportantbranchesofbiosensors,isreviewed.Nanoscalearchitectureshereinvolvenano2particles,nano2wiresandnano2rods,nano2sheet,nano2array,andcarbonnanotub

6、e,etc.Remarkablesensitivityandstabilityhavebeenachievedbycouplingimmobilizedbioactivecompoundsandthesenanomaterials.Keywordsbiosensors;electrochemistrysensors;nanomaterials;bioactivecompounds;immobilization2.3.2NanowiresandnanorodsbasedelectrochemicalContentsbios

7、ensors1Introductiontobiosensors2.3.3Carbonnanomaterialsbasedelectrochemical2Nanomaterialsbasedelectrochemicalbiosensorsbiosensors2.1Challengesanddevelopmentsofbiosensors2.3.4Nanoarraybasedelectrochemicalbiosensors2.2Introductionofnanomaterials2.3.5Nanosheetsbased

8、electrochemicalbiosensors2.3Nanomaterialsbasedelectrochemicalbiosensors3Concludingremarks2.3.1Nanoparticlesbasedelectrochemicalbiosensors收稿:2008年3月,收修改稿:2008年8