nfκb和cjun在大鼠弥漫性轴索损伤中的表达

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1、中文摘要2、NF．1CB和c-jun在损伤后的时序性表达可为损伤时间推断提供一定依据；可为法医病理学推断损伤类型以及推测伤后存活时间提供新的研究方向。关键词：弥漫性轴索损伤；NF．1cB；c-jura凋亡英文摘要ExpressionofNF--KBandc-juninDiffuseAxonalInjuryRatABSTRACTobjective：Diffuseaxonalinjury(DAI)isseriesofpathophysiologicalchangescharacterizedasextensiveaxoninj

2、ury,whichduetotheshear，stretchandcompressionstressinducedbybrain’Saccelerationwhenheadsufferdfromlinearaccelerationand／orrotatoryviolenceattach．ThetypicalperformanceofDAIisdisturbanceofconsciousnessandtheprognosisispoohSevereDAIischaracterizedbyimmediateonsetofcom

3、aatthetimeofinjury,followedbypersistentcomaandvegetativestateorseverepersistentdisability．DAIlargelyaccountedfortheclinicalmanifestationsofbraintrauma．Injurycausedbybraintraumaincludesprimarydamagesandsecondarydamages，andthelatteroneisanimportantfactorofcliniacalt

4、raumaticbraininjury．Moreandmorestudiesshowthatinflammatoryresponseplaysanimportantroleinthesecondarydamagesoftraumaticbraininjury．Recently,studiesindicatethatnuclearfactor-kappaB(NF-1(B)isoneofimportanttranscriptionfactorinfunctionexpressionofnumerouscytokinesandi

5、nflammatoryfactors，andplayanimportantpartintheregulationofInflammatorygeneexpression．JNKsignalingpathway,importantmemberoftheMAPKfamily,Cancauserapidexpressionsofproto-genec．jun，whennervetissuesreceivepathologicalstimulisuchasbleeding，ischemia，hypoxiaortrauma．Ourp

6、reliminarystudyshowedthatnumerousgittercellswereactivatedinratdiffuseaxonalinjury．Pro—inflammatorycytokinesIL一1p、TNF·13tandoxidativefactoriNOSwereincreasedafterinjury,asfollowing，NF—r,Bandc-junwereup—regulatedbytheinflammatoryandoxidationfactors．Therefore，ifthefun

7、ctionofinflammatoryandoxidationfactorsinratdiffuseaxonalinjurywasregulatebyNF—r．Bandc-junworthtodeeplystudy．DAImodelwasestablishedbySprague-Dawley(SD)ratsusinganinjurymodeladaptedfromMarmaroueta1．in1994．TheexpressionofNF一1(B、c-juninDAlwereobservedonthebasisoftheea

8、rlyresearch，andtherelationship4英文摘要betweeninflammatoryandoxidationfactors，NF-KB、c-junandapoptosiswasinvestigated．Furthermore，studytheeffectofNF-KBandc-j