艾灸对大鼠痛经模型血清sic某m-1、svc某m-1等相关因子影响的实验分析

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1、贵阳中医学院硕士学位论文MMP．9表达明显升高，差异有统计学意义(尸<0．01)，艾灸组、西药组比较模型组，子宫内膜MMP．2、MMP．9表达降低，有统计学差异(PO．05)。结论：1．观察艾灸组在实验前后体重平稳增加，说明艾灸对机体的正常生理功能没有影响。各组实验大鼠子宫、卵巢湿重没有差异，说明痛经模型还不足以造成器质性病变。从行为学观察扭体潜伏期，扭体评分和扭体次数，艾灸可有效缓解痛经症状。虽然西药和艾灸的疗效指标并无差异，但是西药实验后体重下降，子宫、卵巢系数升高，可能西药对

2、于机体的还存在一定影响，仍需进一步研究证实。2．艾灸可以抑制血清SICAM．1、SVCAM．1的阳性表达，改善血管内环境。3．艾灸可以抑制子宫内膜MMP．2．MMP．9的阳性表达，减少子宫内膜的损伤。关键词：艾灸；痛经；血清可溶性细胞间粘附分子．1；血管内皮细胞粘附分子．1；基质金属蛋白酶；贵阳中医学院硕士学位论文AbstractObjeetive：Dysmenorrheareferstowomenduringmenstruationandbeforeandaftertheemergenceoflowerabdomenorlo

3、werbackpain，evenpainandlumbosacral．Eachmade、7Irimthemenstrualcycle，maybeassociatedwinlseverenauseaandvomiting，coldsweatdripping，handsandfeetJueleng，andevenfainting，totheworkandlifeimpact．，nlerapiddevelopmentofdomesticmedicine，Chinesemedicineandmodemmedicineco·exist，

4、thisregularityofthedisease，whichmethodissafer,higherefficacy，butalsonon-toxicsideeffects?Andthebesttimeforinterventionisthemostimportant，theexperimentalclassratstudy，startingfromtheinsideandoutsideinterventionandpre-treatment，observedexogenouswesternmedicineandnon-e

5、xogenousdrugsmoxibustionhowdifference?Controlbodyweightofratexperiments；uterus，ovarywetweight；writhingbehavioralresponse；intravascularenvironment-relatedfactors；andpathologicalchangesofimmunohistochemicalmethods．Providetheexperimentalbasisforclinicalapplication．Meth

6、ods：Selectionofhealthynon-pregnantfemalewistarratswererandomlydividedintoblankgroup，modelgroup，moxibustiongroup，medicationgroup，n=8．Inadditiontothecontrolgroup，therestoftheratswereinjecteddiethylstilbestrolinjectionfor10days，No．1，10daysofinjectionO．8mg／onlythefirst2

7、-9daysofinjectionof0．4mg／only．Todiethylstilbestrollast24hafterintraperitonealinjectionofoxytocin2ufonly．Controlgrouptothesamedailydoseofsaline．Aftertheratswererecordedbeforetheexperimentinbodyweight；uterus，ovarywetweight．AccordingSchmaussbehavioralscoring，recording3

8、0minuteswrithinglatencywrithingscoreandwrithing，detectedbyELISAinserumSICAM-l，SVCAM-llevels．PathologicalexaminationusingHEandimmunohistoch