ptx3和肾动脉阻力指数与原发性高血压靶器官损害

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1、山东大学硕士学位论文protein．Whilecurrently，nostudyreportsaboutplasmPTX3inhypertensionpatients．DuetothemajorsourceofPTX3aremacrophagesandendothelialcells，thelevelsofPTX3maybetterreflecttheinflammatorystatusofthevascularbed，andmaybeanimportantmarkerofsubclinicalatherosclerosisandearlyrenalinjuryinprimaryhyperte

2、nsionpatients．Renalarteryresistanceindex(RRI)iswidelyusedinultrasonicdiagnosisofkidneydisease，whichbelievedcanreflectchangesinrenalvascularresistanceanddiagnosisearlykidneydiseaseprogression．PathologicalexaminationconfirmedthattheincreaseofRRIisrelatedtorenalbiopsy，vascularwallthickeningandglomerula

3、rsclerosis．RecentstudieshaveshownthatpositivecorrelationofRRlwithcIMTinpatientsofessentialhypertension，suggestedthatRRImayhavemorecomplicatedpathophysi0109icalsignificanceandmayreflectthechangesinsystemicvascular．ObjeotiVOfl：1．ToinvestigatetheassociationbetweenPTX3，RRIandearlytargetorgandamageinprim

4、aryhypertensivepatients．2．DiscussthepossiblemechanismofPTX3inatherosclerosisofhypertension．MathM：Inourstudy，Werandomlyrecruited60subjectswithprimaryhypertensionfromtheoutpatientcardiovascularclinicsofOiluhospitalfromJune2009toNovember2009，Accordingtoultrasonographyofcarotidartery，thehypertensivepati

5、entsweredividedintotwogroups：hypertension+ASandhypertension—AS．Atthesametime，29age—andsex—matchedsubjectswereenrolled．Allsubjectscompletedaquestionnaireonpresentcondition，includingbloodpress，heartrate，height，weightandSOon．plasmaPTX3levelsweredeterminedby5山东大学硕士学位论文enzymelinkedimmunosorbentassay(ELIS

6、A)．Thediastolicandsystoliclumendiameters(DdandDs)ofcarotidartery，clMTandRRlwereexaminedbyu1trasonography．Dataareexpressedasmeans±SD．Toevaluatestatisticdifferencesbetweengroups，student’Sttestforunpairedvalueswasused．CorrelationsamongvariableswerebasedonanalysisofPearson’Scorrelation，partialcorrelatio

7、n．Moreover，tostudywhethertherewasanindependentrelationshipbetweenPTX3，RRIandmarkersofhypertensionearlytargetorgandamage，multiplelinearregressionwasperformed．P<0．05wasacceptedassignificant．Results：1．Th