独活寄生汤治疗膝骨关节炎临床观察

《独活寄生汤治疗膝骨关节炎临床观察》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、独活寄生汤治疗膝骨关节炎临床观察余建华张衡洛阳市第三人民医院风湿免疫科，河南洛阳471002【摘要】目的观察独活寄生汤治疗膝骨关节炎（OA）的疗效和药物耐受性。方法选择符合纳入标准患者113例，随机分为治疗组和对照组，治疗组56例给予独活寄生汤治疗，对照组57例给予硫酸氨基葡萄糖（GS）治疗，疗程均为4周。采用Lequesne的OA疼痛功能指数对膝关节的症状体征和功能活动进行评分。结果总有效率治疗组为96.43%，对照组为82.45%，两组总有效率比较，差异有显著性意义（P＜0.05），治疗组优于对照组。治疗后两组疼痛功能指数评分均有显著降低，治疗前后比较，差异均有非常显著性意义（P＜

2、0.001），治疗组评分降低优于对照组，差异有显著性意义（P＜0.001）。停药4周后对照组疗效明显降低（与疗程结束时比较P＜0.01），而治疗组疗效降低不明显（与疗程结束时比较P＞0.05）。结论独活寄生汤治疗膝OA疗效明显优于GS组的疗效，且具有较好的安全性。【关键词】独活寄生汤；骨关节炎，膝关节；中医药疗法Duhuojishengtangofkneeosteoarthritisclinicalobservation.YUJian-hua,ZHANGHeng.Rheumatismdepartment,LuoyangThirdPeople’sHospital,Luoyang,Hena

3、n,471002【Abstract】ObjectiveToresearchtheeffectanddrugresistanceofDuhuojishengtangonkneeosteoarthritis(OA).MethodsSelect113patientsmettheinclusioncriteriaWererandomlydividedintotwogroups.Patientsintreatmentgroup(n=56)weretreatedwithDuhuojishengtang.Patientsincontrolgroup(n=57)weretreatedwithGluco

4、saminesulfate.Thetherapeuticcoursewas4weeksinbothgroups.BasedonLequesnefunctionindexofOApainevaluationofSignsandsymptomsofkneejointfunctionalactivities.ResultsThetotaleffective96.43%intreatmentgroup,82.45%incontrolgroup,betweentwogroupsthedifferenceswerestatisticallysignificant(P<0.05),Thetreatm

5、entgroupSuperiorthanthecontrolgroup.twogroupsaftertreatmentthePainandfunctionalindexscoreweresignificantlylower,beforeandaftertreatment,thedifferenceswerestatisticallysignificant(P<0.001),Thetreatmentgroupscorelowerthanthecontrolgroup,thedifferencewasstatisticallysignificant(P<0.001).After4weeks

6、ofwithdrawalefficacyofthecontrolgroupsignificantlydecreased(comparedwiththeendoftreatment,P<0.01),whilethetreatmentgroupwasnotsignificantlylowerefficacy(comparedwiththeendoftreatment,P>0.05).ConclusionDuhuojishengtangeffectofkneeosteoarthritisissuperiortotheefficacyofGlucosaminesulfate,andhasgoo

7、dsecurity.【KeyWords】Duhuojishengtang;osteoarthritis,kneejoint;Chinesemedicinetreatment骨关节炎（osteoarthritis，OA）是一种以关节软骨的变性、破坏及骨质增生为特征的慢性关节病。本病在中年以后多发。临床上以关节肿痛、骨质增生及活动受限最为常见。膝关节作为负重关节是最易受累的关节之一。OA的病因和发病机制至今未明，目前尚无有效治疗办法。本文报道采用独