载溶葡萄球菌酶羟基磷灰石%2f壳聚糖复合缓释材料治疗兔胫骨骨髓炎的实验研究

《载溶葡萄球菌酶羟基磷灰石%2f壳聚糖复合缓释材料治疗兔胫骨骨髓炎的实验研究》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、conductastatisticalanalysiswiththemodifiednordenscoreforosteomyelltlsmeacngroup12weeksaftersurgery,andtheresultssuggestthattherewerestatlstlcalsignificaJlcewhengroupAandBcomparedwithgroupCandDrespectively·WhengroupAcomparedwithgroupB，therewasnostatisticalsignificance，nostatlstlcalsignificance

2、betweengroupCandDtoo．Weconductedastatisticalanalysiswiththelogarithmicofthebacteriacount4and8weeksaftersugery，thebactenacountmgroupAandBarelessthanthebacteriacountingroupCandD，andthedifferencewasstatisticalsignificance．ThebacteriacountingroupAisnotlessthanthebacteriacountingroupB，andthediffer

3、encewasnotstatisticalsignificance，similarresultwas(、btainedwhengroupCcomparedwhitgroupD．SerumbiochemicaltestshowsthatasDanate啪inotransferase(AST)，alanineamiotransferase(ALT)，useanitrogen(BUN)andcreatinine(Cr)intheexperimentalgrouparesimilarwiththecontrolgroup’smeachDhase，andthedifferencewasst

4、atisticalinsignificant．Whenpairwisecomparlsonconductedbetweeneachgroup，therewerenosignificantdifferencetoo·L1Verandkidnevshowednoabnormalchangeshistologicallyintheexperimentalgroup·Conclusions1．W色caninduceanosteomyelitismodelbyinject3x106CFU／mlstaphylococcusaureusbacteriaintotheproximaltibiam

5、edullarythroughasmallaperture(d=lram)，andthismethodwaswellstandardizedandcanbeusedinthefollow—upstudyofosteomyelitis．2．LysostaphinloadedatrigelbyuseofHydroxyapatite／chitosancompositematerialshasacertainabilitytoresistin±ectlon，andcomparedwithvancomycinloadedbyuseofbonecement，theabilitytoresls

6、tinfectionisweakerbuttheabilitytoossifyisstronger．Ithasnoobvioustoxlcandside．ef．fectintheshortterminrabbits．Afterathoroughdebridement，itcanfillinthebonedefectbyfirstintention，SOitisanidealbonefillingmaterialinthetreatmentofchronicosteomyelitis．Keywords：LysostaphinHydroxyapatiteChitosanAntibac

7、terialeffectOsteomyelitis．1V．天津医科大学硕士学位论文缩略语／符号说明英文缩写英文全称中文全称LysoLysostaphin溶葡萄球菌酶HAHydroxyapatite羟基磷灰石CSChitosan壳聚糖HA／CSHydroxyapatite／Chitosan载溶葡萄球菌酶羟基磷灰石／壳聚糖Lyso—HA／CSLysostaphin—Hydroxyapatite／Chitosan载溶葡萄球菌酶羟基磷灰石／壳聚糖SBFSimulatedBodyFluid