可吸收聚酯纳米纤维支架：组成、结构与性能关系-研究

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1、可吸收聚酯纳米纤维支架：组成、结构与性能关系研究propertyandtheproteinadsorptionoftheresultedconduitswereinvestigatedindetail．Finally,thedegradationbehaviorsoftheseconduitsinvitro，suchaschangesinmass，themolecularweight，thethermalproperties，themechanicalpropertiesandthecytotoxicityofdegradationsolutionwerealsoevaluated．Itwas

2、shownthat：(1)Themulti-Channel(痧。。dui。≈3ITllTI，channelnumber：7-16，驴讣。刊≈0．5innl)conduitswithnano-fibrousmicrostructurewasfabricatedforthefirsttime．Theporosityofconduitwasashighas93％，thediameterofnano—fiberwasintherangeof200-300rim．(2)Theproteinadsorptionofnano—fibrousconduitfromPLLA(PLLA／THF)wastwotim

3、esmorethanotherconduits，themasslossinPBSsolutionat37℃wasupto22．5％at2weeks，andtheGPCcurvesofPLLAshowedarandombreakagebehaviorofmolecularchains．ForthePLLA／(Dioxane：H20=88：12，v／v)system，thecompressionmodulusofPLLAconduitwithmicro·-poresandnano-·fibrousporewallwasthreetimesmorethanotherconduits，anditspr

4、oteinadsorptionwashighbutitsdegradationratewasslow．(3)Themulti-channelconduitswithladder-likedporousstructureswerepreparedbyS-LTIPScombiningwithLPIMbasedonPLLAandPLGA(85／15，75／25)also．Thedegreeoforderforladder-likedporousstructureswasdecreasedwiththeincreasingGAsegments，theproteinadsorptionwasdeclin

5、ed，butthecompressivemoduluswasraised．Itwasshownthatthemassloss，thedecreaseofthemolecularweightandthecompressivemodulusofPLLAinPBSwereveryslow,however，forPLGA，thedegradationrateswerefastobviously,whichexhibitedthecharacteristicsofbulkhydrolysis．1HNMRanalysisindicatedthatGAsegmentsdegradedfasterthanL—

6、LAsegmentsinPLGA75／25．MTTtestindicatedthatthedegradationsolutionsoftheconduitswerenosignificantcytotoxicity．2．Fabricationof3Dporousnano-fibrousPCL-b-PLLAscaffoldsThenano—fibrousscaffoldspreparedbypurePLLAwerebrickleanddifficulttocontrolthedegradationrate．Tosolvethisproblem，aseriesofdiblocksemicrysta

7、llinecopolymersofPCL··b··PLLAweredesignedandsynthesizedbybulkringopeningIV中山大学硕士学位论文polymerizationinthepresenceofPCL．OHasmacroinitiatorandstannousisocaprylateascatalyst．Themicrostructureandcrystalprop