资源描述：
《奥沙利铂和吡喃阿霉素介入治疗原发性肝癌疗效和安全性》由会员上传分享，免费在线阅读，更多相关内容在工程资料-天天文库。
1、奥沙利钳和毗喃阿霉素介入治疗原发性肝癌疗效和安全性【摘要】目的：对比分析原发性肝癌采用奥沙利苗和毗喃阿霉素介入治疗的疗效与安全性。方法：选取本院2009年1月-2012年12月收治的76例原发性肝癌患者作为研究对象，按照随机数字表法将其分为为研究组与对照组各38例。研究组患者采取毗喃阿霉素介入治疗，对照组则采取奥沙利钳介入治疗。观察比较两组患者治疗效果与安全性，疗效包括总有效率、疾病控制率、临床症状改善率、肿瘤标志物的下降率、疾病进展时间、不良反应发生率等；分析两组中进展时间大于12个月的患者情况，来判断介入治疗远期疗效的影响因素。结果：研究组治疗总有效率、平均疾病
2、无进展时间和肿瘤标志物下降率均明显优于对照组，比较差异有统计学意义（P0.05）。通过分析可知，介入治疗远期疗效的影响因素包括门静脉受累、病灶有无包膜及术后合并应用抗癌药物等。结论：原发性肝癌患者采用毗喃阿霉素介入治疗，有着安全与有效的优势，同时能提高疾病无进展时间,相较于毗喃阿霉素介入治疗效果更佳，值得临床推广及应用。【关键词】奥沙利卒白;毗喃阿霉素;介入治疗；原发性肝癌；疗效；安全性EfficacyandSafetyofOxaliplatinandPirarubicinInterventionintheTreatmentofPrimaryLiverCancer/
3、LIUXiao-hong,WANLin-lin,DINGWei,etal.//MedicalInnovationofChina,2013,10(35)：021-023[Abstract】Objective：ToanalyzeandcomparetheefficacyandsafetyofOxaliplatinandPirarubicininterventiononprimarylivercancer.Method:Seventy-sixprimarylivercancerpatientsinourhospitalfromJanuary2009toDecember20
4、12wereselectedastheresearchobjects,andthenrandomlydividedintothestudygroupandthecontrolgroup,38casesineachgroup.Thestudygroupwastreatedwithpirarubicinintervention,thecontrolgroupwastreatedwithinterventionaltherapy.Theeffectandsafetycomparisonoftwogroupswereanalyzed,includingtheincidenc
5、eofclinicaltotaleffectiverate,diseasecontrolrate,clinicalsymptomimprovementrateofdecline,therateoftumormarkers,timetoprogression,adversereaction；Timetoprogressionthanpatientsinthetwogroupsof12monthswereanalyzed,anddeterminedthefactorsthataffectonthelong-termeffectofinterventionaltherap
6、yResuIt:Thetotaleffectiverate,averageprogressionfreesurvivalandtumormarkerdeclinerateofthetreatmentgroupwerebetterthanthoseofthecontrolgroup,thedifferenceswerestatisticallysignificant(P0.05)・Throughtheanalysis,factorsaffectingthelong-termeffectofinterventionaltreatment,includingportalv
7、eininvolvement，lesionswerenonenvelopedandpostoperativecombinedwithanticancerdrugs.Conclusion：Inpatientswithprimarylivercancerwithpirarubicininterventiontherapy,isasafeandeffective,andcanimprovetheprogressionfreesurvival,comparedwithpirarubicininterventiontherapyeffectisbetter,itiswor
