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1、NZY_]ZW+_SPZ]d+LYO+^d^_PX^+MTZWZRdpotÄpo+mÖ+{lmwz+l9+trwp~tl~+lyo+m}tly+{9+tyrlww~ControlTheoryandSystemsBiologyControlTheoryandSystemsBiologyeditedbyPabloA.IglesiasandBrianP.IngallsTheMITPressCambridge,MassachusettsLondon,England62010MassachusettsInstituteofTechnologyAllrightsre
2、served.Nopartofthisbookmaybereproducedinanyformbyanyelectronicormechanicalmeans(includingphotocopying,recording,orinformationstorageandretrieval)withoutpermissioninwritingfromthepublisher.MITPressbooksmaybepurchasedatspecialquantitydiscountsforbusinessorsalespromotionaluse.Forinf
3、ormation,pleasee-mailspecial_sales@mitpress.mit.eduorwritetoSpecialSalesDepartment,TheMITPress,55HaywardStreet,Cambridge,MA02142.ThisbookwassetinTimesNewRomanon3B2byAscoTypesetters,HongKong.PrintedandboundintheUnitedStatesofAmerica.LibraryofCongressCataloging-in-PublicationDataCo
4、ntroltheoryandsystemsbiology/editedbyPabloA.IglesiasandBrianP.Ingalls.p.cm.Includesbibliographicalreferencesandindex.ISBN978-0-262-01334-5(hardcover:alk.paper)1.Biologicalcontrolsystems.2.Controltheory.I.Iglesias,PabloA.,1964–II.Ingalls,BrianP.,1974–[DNLM:1.BiochemicalPhenomena.2
5、.CellPhysiologicalProcesses.3.Feedback,Biochemical—physiology.4.Models,Biological.5.SystemsBiology.QU34C7642010]QH508.C672010571.7—dc22200900707510987654321ContentsPrefacevii1APrimeronControlEngineering1BrianP.IngallsandPabloA.Iglesias2ModelingandAnalysisofStochasticBiochemicalNe
6、tworks29MustafaKhammash3SpatialModeling45PabloA.Iglesias4QuantifyingPropertiesofCellSignalingCascades69SimoneFrey,OlafWolkenhauer,andThomasMillat5ControlStrategiesinTimesofAdversity:HowOrganismsSurviveStressfulConditions85HanaEl-Samad6SyntheticBiology:ASystemsEngineeringPerspecti
7、ve101DomitillaDelVecchioandEduardoD.Sontag7GraphsandtheDynamicsofBiochemicalNetworks125DavidAngeliandEduardoD.Sontag8AControl-TheoreticInterpretationofMetabolicControlAnalysis145BrianP.Ingalls9RobustnessandSensitivityAnalysesinCellularNetworks169JasonE.Shoemaker,PeterS.Chang,Eric
8、C.Kwei,StephanieR.Taylor,andFrancisJ.Doy