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1、小儿难治性癫痫的诊断和治疗研究进展刘晓燕（100034北京，北京大学第一医院儿科）[关键词]难治性癫痫；诊断；治疗；抗癫痫药物；癫痫外科；生酮饮食；儿童[中图法分类号][文献标志码]AProgressindiagnosisandtreatmentforpediatricrefractoryepilepsyLiuXiaoyan(DepartmentofPeadiatricsofPekingUniversityFirstHospital,Beijing,100034,China)[Abstract]Thepathogenesisofpediatricrefractoryepi
2、lepsyinvolvesavarietyoffactors,includinghereditarypredisposinggenes,abnormalneuralnetworkforms,drugresistancegenes,autoimmunemechanisms,etc.Refractoryepilepsyindevelopingchildrenoftenhasevolutioninseizuretypes,EEGcharacteristics,courseofdiseaseandprognosis.Theresponsetoantiepilepticdrugs(
3、AEDs)isnotonlydependentontheseizuretypes,butalsorelatedtotheepilepticmechanismsandsyndrometypes.InadditiontoAEDstreatment,nonconventionaltherapiesareoftenneeded,suchascorticosteroids,intravenousimmunoglobulin(IVIG),ketogenicdiet,epilepticsurgeryandvagusnervestimulation.Becauseofthevariati
4、onandindeterminatenessinseizuretypes,thesyndrometypesandlocalizationofseizureonsetinepilepticencephalopathyisveryimportantforcautiouslyselectingindicationsandcarryingoutsufficientpreoperativeevaluationforepilepticsurgerytreatment.[Keywords]refractoryepilepsy;diagnosis;treatment;antiepilep
5、ticdrug;epilepticsurgery;ketogenicdiet;childhoodCorrespondingauthor:LiuXiaoyan,E-mail:dr_lxy@sina.comProgressindiagnosisandtreatmentforrefractoryepilepsiesinchildhoodLiuXiaoyan(DepartmentofPeadiatricsofPekingUniversityFirstHospital,Beijing,100034,China)[Abstract]Thepathogenesyofrefractory
6、epilepsiesinchildhoodinvolvedinvarietyfactors,includinghereditarypredisposinggenes,abnormalneuralnetworkform,drugresistancegenes,autoimmunemechanismsandsoon.Refractoryepilepsiesindevelopingchildrenoftenhadevolutiononseizuretypes,EEGcharacteristics,courseofdiseaseandprognosis.Theresponseto
7、antiepilepticdrugs(AEDs)notonlydependenttoseizuretypes,butalsorelatedtoepilepticmechanismandsyndrometypes.InadditiontoAEDstreatment,noconventionaltherapiesoftenneeded,suchascorticosteroidsorIVIG,ketogenicdiet,epilepticsurgeryorvagusnervestimulation.Becauseofvariatio
