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1、437例冷冻胚胎移植结果相关影响因素研究[摘要]目的探讨冷冻胚胎移植(FET)结果的相关影响因素。方法回顾性分析2008年1月〜2012年6月在广东省妇幼保健院生殖中心进行FET周期中437例患者的临床资料,探讨年龄、子宫内膜准备方案、子宫内膜厚度、胚胎类型及移植时间对FET结果的影响。结果获得临床妊娠171例(39.14%),子宫内膜厚度0.05);年龄、与移植细胞胚胎类型及移植时间选择排卵后第3天或第4天这两组间的临床妊娠率差异有统计学意义(P10个细胞期单胚胎/M期胚胎及2或3个M期胚胎均可增加妊娠率,而后者妊娠成功的可能性更大(0R=3.225、4.671)o
2、移植时间选择排卵后4d(自然周期)或者黄体酮(40mg/d)转化4d相对于3d者其妊娠可能更大(0R二1.986)。结论患者年龄、子宫内膜的准备、胚胎类型和数目、移植时间选择均可对FET的结果造成影响。[关键词]冷冻胚胎移植;妊娠率;影响因素[中图分类号]R711.6[文献标识码]A[文章编号]1673-7210(2013)11(c)-0048-04Analysisofinfluencingfactorson437casesfrozen-thawedembryotransferDONGMeiYIYanhongCHENChuangqiLIUFenghuaHUANGCui
3、yuZHANGXiqianDepartmentofReproductiveHea1thandInfertility,GuangdongWomenandChildrenHospital,GuangdongProvince,Guangzhou510403,China[Abstract]ObjectiveToexploretheinfluencingfactorsonfrozen-thawedembryotransfer(FET).MethodsClinicaldatasof437patientsinFETcyclesfromJanuary2008toJune2012int
4、heReproductiveCenterofGuangdongWomenandChildrenHospitalwereretrospectiveanalyzed・Theage,preparationprogramsofendometriumfortransfer,endometriumthickness,embryotypes,andtheimplantationtimeofcryopreservedhumanembryowerediscussed.Results171(39・14%)patientsacquiredclinicalpregnancy,therewas
5、nosignificantdifferencebetweenthepatientswhoseendometriumthickness0.05),theclinicalpregnancyrateindifferentageandembryotypes,andclinicalpregnancyrateindifferenceimplantationtimeof3and4daysafterovulationhadsignificantdifference(P10orMperiodembryos,and2or3Mperiodembryoswereincreased,andth
6、elateronehadahigherodds(OR二3.225,4.671).ThepregnancyrateafterFETwasincreasedinthe4daysafterovulation(natura.lperiod)ortheProgesterone(40mg/d)conversion4dayshadahigherpregnancyratethanthe3days(OR二1.986).ConclusionTheageofPatients,preparationofendometrial,typesandnumberofimplantationembry
7、o,andthechoiceofFETtimecouldinfluencetheimplantationresuIt.[Keywords]Frozen-thawedembryotransfer;Pregnancyrate;Influencefactors自1994年北京大学第三医院完成我国首例冻融胚胎移植妊娠以来[1],冷冻胚胎移植(frozen-thawedembryotransfer,FET)技术在国内得到飞速发展。FET具有降低多胎妊娠率、促排卵次数、预防重度卵巢过度刺激综合征、提高累积妊娠率及降低费用等方面的优点,已成为辅助生殖技术的重要组成