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1、DrugDiscoveryTodayVolume21,Number3March2016PERSPECTIVEfeatureThechangingmodelofbigpharma:impactofkeytrendsAjayGautam,ajay.gautam@astrazeneca.comandXiaogangPanRecentyearshaveseenexcitingbreakthroughsinbiomedicalsciencesthatareproducingtrulynoveltherapeuticsforunmetp
2、atientneeds.However,thepharmaceuticalindustryisalsofacingsignificantbarriersintheformofpricingandreimbursement,continuedpatentexpirationsandchallengingmarketdynamics.Inthisarticle,wehaveanalyzeddatafromthe1995–2015period,onkeyaspectssuchasrevenuedistribution,researchu
3、nits,portfoliomixandemergingmarketstoidentifyfourkeytrendsthathelptounderstandthechangeinstrategicfocus,realignmentofR&Dfootprint,theshiftfromprimarycaretowardspecialtydrugsandbiologicsandthegrowthofemergingmarketsasmajorrevenuedriversPERSPECTIVEforbigpharma.Feature
4、sIntroductionWecollecteddataacrossdifferentparametersmassivetolean;suchBigpharmahasseenasignificantchangeinas:revenuepercentagefrombiologics,hubstohotspots;operatingmodelandfootprintoverthepastspecialtyandprimarycareportfolios;mergersprimarytospecialty;coupleofdec
5、ades.Severalstudieshavereviewedandacquisitions;regionalgrowthrates;researchWesttoEast.theindustry’sdecliningproductivitychallengesfootprintandsitesglobally;revenuesplitbe-Eachofthesetrendsandtheimpactonthebig[1,2],thetransitioningofcommercialmodels[3,4]tweentheestabl
6、ished(USA,EuropeandCanada)pharmaoperatingmodelisdiscussedinmoreandthegrowthofemergingmarketsaskeyandtheemerging(Asia,LatinAmerica,Russia,detailbelow.revenuecontributors[5].Inthisarticle,wehaveMiddleEastandAfrica)markets;amongothers.reviewedthekeytrendsthathaveimpacte
7、dandWeusedpublicandproprietarysourcessuchasThekeytrendsimpactingthebigpharmatransformedthebigpharmacompaniesovertheIMSHealth(http://www.imshealth.com/),com-modelpast20years.Thecurrentbigpharmamodelispanyannualfilings,industryreportsandpressMassivetoleantransitioningto
8、thatofalean,focusedcompanyreleasesforthetop12innovation-drivenphar-The1995–2005periodwasmarkedwithintensewitharesearchfootprintwith
