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1、实用标准文案【摘要】 目的:探讨氨茶碱对急进高原者抗缺氧的效应。方法:总共100名青年男性入选本试验。随机分为2组:氨茶碱组50名(A组),对照组50名(C组)。所有参试者均为从四川省(海拔400米)招募的新兵。在乘飞机从四川进入拉萨(海拔3658米)前7d,A组和C组分别开始口服氨茶碱和安慰剂。在3个时间点(服药前、服药后7d、进入高原后3d)抽血测定血浆一氧化氮(NO)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、过氧化氢(H2O2)、乳酸(LA)和动脉血氧饱和度(SaO2)。结果:在平原地区服药前、后两组的缺氧和氧化指标比较无统计学差异。进入高原后3d,所有
2、参试者的血浆SOD,CAT(仅对照组),H2O2,LA水平增加(P<0.01),NO,SaO2下降(P<0.05,<0.01)。A组的SOD,CAT,H2O2,LA水平较C组低(P<0.01),而NO和SaO2水平高于C组(P<0.05,P<0.001)。结论:氨茶碱具有抗高原缺氧和抗氧化作用。【关键词】高原病 缺氧 氨茶碱 Anti
3、hypoxiaeffectofaminophyllineonsubjectswithacutehigh
4、altitudeexposure/YANGBo,WANGGuang
5、yi,CHENBin,QINRong
6、bin,ZHAXi,CHE
7、NLian// Abstract:Objective:Toinvestigatetheanti
8、hypoxiaeffectofaminophyllineonsubjectswithacutehigh
9、altitudeexposure.Methods:Totally100youngmalesubjectswereenrolledinthisstudy.Theywererandomlydividedintotwogroups:aminophyllinegroup(Agroup,50cases)andcontrolgroup(Cgroup,50cases).Theywere
10、allnewlyengagedarmymembersrecruitedfromSichuanprovince(400metersabovesealevel).SubjectsofAgroupandCgrouporallytookaminophyllineandplaceborespectively7daysbeforetheyenteringLhasa(3658mabovesealevel)byairplane.Theserumlevelsofnitricoxide(NO),superoxidedismutase(SOD),catalase(CAT),hydrogend
11、ioxide(H2O2),lacticacid(LA),andarterialoxygensaturation(SaO2)weremeasuredat3timepoints:beforedrugtaken,7daysafterdrugtaken,and3daysafterascendingtohigh
12、altitude.Results:Therewerenostatisticaldifferencesbetweentwogroupsinhypoxiaandoxidationindicatorsbeforeandafterdrugusedatplainarea.These
13、rumlevelsofSOD,CAT(onlycontrolgroup),H2O2,LAincreased(P<0.01)andNO(P<0.05),SaO2(P<0.01)decreasedmarkedlyinallsubjects3daysafterascendingtohigh
14、altitude.TheserumlevelsofSOD,CAT,H2O2andLAinAgroupweremuchlowerthanthoseinCgroup(P<0.01).Meanwhile,theNOandSaO2levelsinAgroupwerehigherthanthosei
15、nCgroup(P<0.05,P<0.001respectively).Conclusion:Aminophyllinehassignificantanti
16、hypoxiaandanti
17、oxidationeffectsathighaltitude. Author′s address:DepartmentofCardiology,ChinesePLAGeneralHospital,Beijing,100853,China Keywords:High
18、altitudedisease;Hypoxia;Aminophylline 每年数以