补肺活血胶囊中黄芪的物质基础分析

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1、硕士学位论文ABSTRACTABSTRACTObjectiveStudyonthematerialbasisofRadixAstragaliinbufeihuoxueeaPsulewithPharmacyandPharmaeokinetiesPointofview.OPtimizeRadixAstragaliextractionandPurifieationProeesswiththemaineomPonentelementsofmatterasanindex.EstablishthedraftqualitystandardsofRadixAstragaliextrac

2、t.Laythefoundationforthedevelop力。entofbufeihuoxueeaPsule.MethodIn面5study，highPerformanceliquidehromatograPhyandulti妞violetsPectrOPhotometrywasusedtoanalysisthemajoreomPonentseontainedintheext拢LctofRadixAstragali.ThemateriaibasisofRadixAstragaliwasinitiallyidentifiedwithinvivointestinalPe

3、dhsionmodel，thePlasmaticandurin呷eonstituentsofRadlxAs加galianalysis.Thematerialbasiswaseonsideredastheindex，usedtheorthogonalexPerimentaldesigntoOPti面zationofextractionProcessofRedixAstragali.DetenninetheenrielunentofRadixAs恤galiextractPurifieation.Developmeniofquaiitystarldardsextractacc

4、ordingtothegeneralrequin沈nentsfor~drugdeveloPment.ResuitTheflavonoidsofRadixAstragali’5seParationwasaehievedonaAgilentTC一C18eolumn(250x4.6刀以们口，5林m)，monitoredbyUV比50印tionatZo3nmand叩eratedat1.omL·而n.，usingthegradientelutionofAeetonitrileandwater.DetenninationofSaponinsintheextractofRadixAs

5、tragaliwasPefformedbyUVsPeetroPhotometrymonitoredbyUVabsorptionat544nm.IniestinalPe而sionexPeriments，RadixAStragaiiextracteightkindsofmainflavonoidseomPonenisandsaponinsareabsothedtovarylngdegrees.intothebloodconstituentsinPoorreProducibilityofthethreeresultsareobtainedwiththenumberofcomP

6、onentPeaksweres，3，3;intotheurinaryeonstituents，targeteonstituentsbythenumberofPeaksfor4.Confirmedtheinitialstructure，twooftheeightkindsofflavonoidsarecalycosinandformononetin.TheeightkindsofmainflavonoidseomPonentsandsaPoninsaretheRadixAstragaliinbufeihuoxueeaPsulePlayinthematerialbasisf

7、or111了硕士学位论文ABSTRACTefficaey.Calyeosin，formononetinandsaPoninsareconsideredastheindextooPtimizatetheProeessofextraetionandPurifieation.OPtimalextraetionProeessofRadixAstragali:RadixAstragalifollowedby12times，9timestheamouniof80%ofethanoltwiee，each1hour.Purifieationshowedt