早产儿甲状腺功能检测及临床意义

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1、［摘要］目的探讨早产儿血清甲状腺功能检测及临床意义。方法将我院2008年1月〜2010年3月收治的早产儿100例分成两组：A组50例，胎龄＜34周；B组50例，胎龄234周，对照组为同期出生的正常足月新生儿50例。应用放射免疫法对3组新生儿生后第1、8天血清三碘甲状腺原氨酸（T3）、甲状腺素（T4）、促甲状腺激素（TSH）水平进行检测。结果三组新生儿T3、T4、TSH水平于生后1〜8d呈下降趋势，A、B组13、T4第1、8天均低于对照组，A组低于B组；生后第1天，A、B组TSH低于对照组，A组高于B组；生后第8天，A组

2、TSH均高于B组和对照组，B组和对照组无明显差异。结论早产儿生后甲状腺功能有暂时性低下，胎龄越小，功能越低，生后应激反应持续时间越长。［关键词］早产儿；胎龄；甲状腺功能低下；下丘脑■垂体-甲状腺轴［中图分类号］R581［文献标识码］B［文章编号］1673-9701(2011)33-140-02ClinicalSign讦icanceofThyroidFunctionDetectioninPrematureInfantsZHOUSuyaCHENQingDepartmentofPediatrics,theSixthPeopl

3、e'sHospitalofHangzhouCityinZhejiangProvince，Hangzhou310014,China[Abstract]ObjectiveToexplorethethyroidfunctioninprematureinfants.MothodsSerumtriiodothyronine(T3)，thyroxine(T4)andthyrotropin(TSH)weredetectedbyradioimmunoassay(RIA)in100prematureinfantsonthe1stand8

4、thdaysafterbirthfromJan2008toMar2010.Theyweredividedintotwogroupsaccordingtothegestationalage：50casesinthegroupA，lessthan34weeksofgestationalage,and50casesingroupB,34-37weeksofgestationalage.50normalneonatecomposedcontrolgroup・ResultsTheconcentrationsofserumT3,T

5、4,TSHshowedadecliningtendencyinallneonatesfromthe1stdaytothe8thdayafterbirth.TheconcentrationsofserumT3,T4onthe1stand8thdayweresignificantlyloweringroupAandgroupBthanthoseinthecontrols,andthoseingroupAwerealsosignificantlylowerthanthoseingroupB；Onthe1stdayafterb

6、irth,theserumTSHweresign讦icantlyloweringroupAandgroupBthanthoseinthecontrols,andthoseingroupAweresignificantlyhigherthanthoseingroupB；Onthe8thdayafterbirth,theserumTSHingroupAwerehigherthanthoseingroupBandcontrols,whereastheserumTSHwerenotsignificantlydifferentb

7、etweenBandcontrols.ConclusionThethyroidfunctionintheprematureinfantsistransientlylow.Theshorterthegestationalage,thelowerthethyroidfunctionandtheIongerthestressreaction.[Keywords]Prematureinfants；Gestationalage；Lowthyroidfunction；Hypothalamus・pituitary・thyroidgl

8、and先天性甲状腺功能低下症的筛查在我国已十分普及，随着对新生儿甲状腺功能的深入理解以及早产儿及低出生体重儿的日益增多，关于早产儿生后甲状腺功能的研究也逐渐增多。近年发现，部分早产儿临床上有甲状腺功能低下的表现，为进一步了解早产儿甲状腺功能状态，笔者对我院收治的早产儿甲状腺功能进行前瞻性检测并分析规律，现总结如下。1资料与方法1.