《measles麻疹》ppt课件

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1、MEASLESFenHuaChen,M.D.,PhD.DepartmentofPediatrics,TheThirdAffiliatedHospitalSunYat-senUniversityMeaslesis…anacuteviralinfectioncharacterizedbyamaculopapularrasheruptingsuccessivelyovertheneck,face,body,andextremitisandaccompaniedbyahighfever.DEFINITIONETIOL

2、OGYMeaslesvirusAnRNAvirusofthegenusMorbillivirusinthefamilyofParamyxoviridaeOneserotype,human’sonlyhostStableantigenicityRapidlyinactivatedbyheatandlightSurvivalinlowtemperature.EPIDEMIOLOGYInfectionsourcesPatientsofacutestageandviralcarriersofatypicalmeasl

3、esTransmissionHighlycontagious,approximately90%ofsusceptiblecontactsacquirethedisease.Respiratorysecretions:maximaldisseminationofvirusoccursbydropletsprayduringtheprodromalperiod(catarrhalstage).Contagiousfrom5daysbeforesymptoms,5daysafteronsetofrashSeason

4、s:inthespring,peakinFeb-MayPATHOGENESISANDPATHOLOGYPortalofentryRespiratorytractandregionallymphnodesEntersbloodstream(primaryviraemia)monocyte–phagocytesystemtargetorgans(secondaryviraemia)TargetorgansTheskin;themucousmembranesofthenasopharynx,bronchi,an

5、dintestinaltract;andintheconjunctivae,ectResultingIn-----1)Koplikspotsandskinrash:serousexudationandproliferationofendothelialcellsofthecapillaries,vasculitis2)ConjunctivisPATHOGENESISANDPATHOLOGY3)Laryngitis,croup,bronchitis:generalinflammatoryreaction4)Hy

6、perplasiaoflymphoidtissue:multinucleatedgiantcells(Warthin-Finkeldeyreticuloendothelialgiantcells)maybefound5)Interstitialpneumonitis:Hechtgiantcellpneumonia.6)Bronchopneumonia:duetosecondarybacterialinfections7)Encephalomyelitis:perivasculardemyelinization

7、occursinareasofthebrainandspinalcord.8)Subacutesclerosingpanencephalitis(SSPE):degenerationofthecortexandwhitematterwithintranuclearandintracytoplasmicinclusionbodiesCLINICALMANIFESTATIONTypicalManifestation:patientshavn’thadmeaslesimmunization,orvaccinefai

8、lurewithnormalimmunityorthosehavn’tusedimmuneglobulin1.Incubationperiod(infectiontosymptoms):6-18days(average10days)2.Prodromalperiod:3-4daysNon-specificsymptoms:fever,malaise,anorexia,headacheClassica