下肢动脉硬化闭塞症介入治疗疗效与危险因素分析

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1、-第三军医大学硕士学位论文缩略语表英文缩写英文全称中文全称ABIAnkle-brachialindex踝肱指数ASAtherosclerosis动脉粥样硬化ASBPAnklesystolicbloodpressure踝部收缩压BMIBodymassindex体重指数BSBPBrachialsystolicbloodpressure前臂收缩压hs-CRPHigh-sensitiveCreactiveprotein高敏C-反应蛋白DBPDiastolicbloodpressure舒张压FPGFastingplasma

2、glucose空腹血糖GLUT4Glucosetransporter葡萄糖转运子4HbA1cGlycosylatedhemoglobinA1c糖化血红蛋白HDL-cHigh-densitylipoproteincholesterol高密度脂蛋白胆固醇IGTImpairedglucosetolerance糖耐量异常IMTIntima-mediathickness内膜—中膜厚度IRInsulinresistance胰岛素抵抗IRS1Insulinreceptorsubstaste-1胰岛素受体底物1LDL-cLow-

3、densitylipoproteincholesterol低密度脂蛋白胆固醇LEAODLowerextremityarterialocclusivedisease下肢动脉硬化闭塞症MSMetabolicsyndrome代谢综合征PADPeripheralarterioscleroticdisease周围动脉硬化病PTAPercutaneoustransluminalangioplasty经皮腔内血管成形术RBP4Retinolbindingprotein4视黄醛结合蛋白4SBPSystolicbloodpress

4、ure收缩压TASCTrans-AtlanticInter-SocietyConsensus泛大西洋学会联盟TCTotalcholesterol总胆固醇T2DMType2diabetesmellitus2型糖尿病TGTriglyceride甘油三酯TNF-αTumornecrosisfactor-alpha肿瘤坏死因子-αVLDLVerylowdensitylipoprotein极低密度脂蛋白1---第三军医大学硕士学位论文Long-termprognosisofinterventionaltherapyinpa

5、tients withlowerextremityarterialocclusivediseaseanditsriskfactorsAbstractAlongwiththeimprovementoflivingstandard,theprevalenceofLowerextremityarterialocclusivedisease(LEAOD)isalsoincreasing,whichhasbecomeanimportantcauseoflowerextremityamputationandgreatlyaf

6、fectsthepatients’lifequality.Currently,Percutaneoustransluminalangioplasty(PTA),includingballoondilatationandstentimplantation,hasbeenregardedasthemostwidelyappliedandacceptedtreatmentforLEAOD.Thetherapeuticeffectsoflowerextremityinterventionaltreatment,varie

7、dindifferentreportareas.Itwasreportedthatthetherapeuticeffectswereinfluencedbysometraditionalriskfactors,includingage,gender,smoking,andsoon.Moreover,recentstudiesalsoshowedthatsomeadipocytokinesandinflammatoryfactorsalsoplayacrucialpartinthepathologicalproce

8、ssofLEAOD.Thedifferenceoftherapeuticeffects,theendpointevents,theinflammatoryfactorsandtheadipocytokineswerecomparedbetweeninterventionalandconventionaltreatmentgrouptoanalyzetheeffectofi