elf1在胃癌组织中的表达及其临床意义论文

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1、Elf1在胃癌组织中的表达及其临床意义论文【摘要】目的探讨转录因子Elf1在胃癌组织中的表达及其与胃癌临床病理学特征的关系。方法采用免疫组织化学染色的方法检测70例胃癌组织及相应的癌旁组织、远癌黏膜组织中Elf1的表达，分析Elf1表达与胃癌及其临床病理特征的关系。结果Elf1在胃癌、癌旁组织、远癌黏膜组织中表达的阳性率分别为88.6%、55.7%、5.0%，Elf1在胃癌中的表达率明显高于癌旁组织及远癌黏膜组织，差异有显著性（Hc=70.11,P0.01）；Elf1在胃癌中的表达与分化程度、

2、浸润深度、临床分期及淋巴结转移有关（Hc=-4.81～19.62，P0.01）。结论Elf1与胃癌的发生及发展有关，检测Elf1的表达水平对于胃癌早期诊断及预后评估具有重要参考价值。【关键词】Elf1癌基因胃肿瘤免疫组织化学［ABSTRACT］ObjectiveToinvestigatetheexpressionofElf1inhumangastriccarcinomaanditsrelationtoclinicalpathology.MethodsElf1expressionsincance

3、rtissueandadjacentanddistalmucosa,in70cases,munohistochemistry.Therelationshipbetucosabeingsignificant(Hc=70.11,P0.01).Elf1expressionphnodemetastasis(Hc=－4.81-19.62,P0.01).ConclusionElf1isinvolvedintumorigenesisandprogressionofgastriccancer.Thedetection

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