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1、钙离子拮抗剂中毒的临床救治论文近年来，钙离子拮抗剂的临床应用日益增多，用药过量引起中毒的情况时有发生。钙离子拮抗剂主要是通过阻滞钙离子L型通道抑制心血管组织的钙离子内流，从而使血管平滑肌松弛、心肌收缩力下降、心率减慢。因此，用药过量可导致心输出量下降、严重心动过缓、低血压和休克。同时，还能抑制胰岛β-细胞钙离子内流，导致血糖升高和胰岛素相对不足，从而影响正常能量代谢和心肌细胞对碳水化合物的利用1。钙离子拮抗剂中毒的救治措施主要有去除药物.freelericanAcademyofToxicology,EuropeanAssociationofPoisonsCentres
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