《氨基葡萄糖》word版

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1、氨基葡萄糖危险性glucosaminedoesnotcauseglucoseintoleranceandhasnodocumentedeffectsonglucosemetabolism.[41]氨基葡萄糖不会导致葡萄糖不耐症并且没有资料显示对葡萄糖代谢有影响。（AndersonJW,NicolosiRJ,BorzellecaJF(February2005)."Glucosamineeffectsinhumans:areviewofeffectsonglucosemetabolism,sideeffects,safetyconsiderat

2、ionsandefficacy".FoodandChemicalToxicology43(2):187–201.doi:10.1016/j.fct.2004.11.006.PMID15621331.(StudyfinanciallysupportedbyCargillIncorporated,amanufacturerofglucosamineasacknowledgedinthepaper.）Otherstudiesconductedinleanorobesesubjectsconcludedthatoralglucosamineatst

3、andarddosesdoesnotcauseorsignificantlyworseninsulinresistanceorendothelialdysfunction.[42][43][44]其他对瘦弱或肥胖例子研究得出的结论是，口服标准剂量的葡萄糖不会导致或显著恶化胰岛素抵抗或血管内皮功能障碍。（MuniyappaR,KarneRJ,HallGetal.(November2006)."Oralglucosaminefor6weeksatstandarddosesdoesnotcauseorworseninsulinresistance

4、orendothelialdysfunctioninleanorobesesubjects".Diabetes55(11):3142–50.doi:10.2337/db06-0714.PMID 17065354. ）（PouwelsMJ,JacobsJR,SpanPN,LuttermanJA,SmitsP,TackCJ(May2001)."Short-termglucosamineinfusiondoesnotaffectinsulinsensitivityinhumans".TheJournalofClinicalEndocrinolog

5、yandMetabolism86(5):2099–103.doi:10.1210/jc.86.5.2099.PMID 11344213. ）（BiggeeBA,BlinnCM,NuiteM,SilbertJE,McAlindonTE(February2007)."Effectsoforalglucosaminesulphateonserumglucoseandinsulinduringanoralglucosetolerancetestofsubjectswithosteoarthritis".AnnalsoftheRheumaticDis

6、eases66(2):260–2.doi:10.1136/ard.2006.058222.PMC 1798503.PMID 16818461.http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1798503. ）生物利用度和药代动力学BioavailabilityandpharmacokineticsTworecentstudiesconfirmthatglucosamineisbioavailablebothsystemicallyandatt

7、hesiteofaction(thejoint)afteroraladministrationofcrystallineglucosaminesulfateinosteoarthritispatients.Steadystateglucosamineconcentrationsinplasmaandsynovialfluidwerecorrelatedandinlinewiththoseeffectiveinselectedinvitrostudies.[45][46]最近的两项研究证实，骨性关节炎患者在口服结晶氨基葡萄糖硫酸钠盐后，其组织

8、系统和骨节处是可利用氨基葡萄糖的。稳态的氨基葡萄糖血浆和滑液浓度是呈正相关的。（PersianiS,RodaE,RovatiLC,LocatelliM,GiacovelliG,R