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1、氧化樟脑注射液对小鼠睡眠功能等影响的实验研究焦燕，杨晓春，张问，杨世杰，李红＊（吉林大学白求恩医学院药理学系，吉林长春130021）摘 要:目的:探讨氧化樟脑对小鼠睡眠功能和自主活动的影响。方法:①腹腔注射氧化樟脑10min后,腹腔注射阈剂量的戊巴比妥钠（45mg/kg）,记录小鼠入睡时间和睡眠持续时间。②腹腔注射戊巴比妥钠（65mg/kg）,待小鼠翻正反射消失后,腹腔注射氧化樟脑,记录小鼠睡眠时间。③小鼠腹腔注射氧化樟脑,10min后放入YLS-1S多功能小鼠自主活动测定仪中,稳定2min后记录5min内小鼠自主活动次数。结果:①氧化樟脑能显著延长阈剂量戊巴比妥钠的小鼠的入睡时
2、间并缩短睡眠持续时间。②氧化樟脑能显著缩短阈上剂量戊巴比妥钠小鼠的睡眠时间,与对照组比较，具有明显的统计学差异(P<0.05或P<0.01)。③氧化樟脑明显的增加了小鼠自主活动次数。结论:氧化樟脑能够延长小鼠入睡时间、缩短睡眠时间并增加小鼠的自主活动次数，提示具有催醒的作用。关键词:氧化樟脑；戊巴比妥钠；睡眠；自主活动Effectstudyofoxcamphorinjectiononmice’ssleepfunctionandotherfunctionJIAOYan,YANGXiao-chun,ZHANGWen,YANGShi-jie,LIHong(DeptofPharmacol
3、ogy,NormanBethuneCollegeofMedicine,JinlinUniversity,Changchun130021,China)Abstract:Objective:Itistoinvestigatetheeffectofoxcamphorinjectiononmice’ssleepfunctionandspontaneousactivity.METHODS:①intraperitonealinjectionofcamphoroxidationafter10min,ofintraperitonealinjectionthethresholddoseofpent
4、obarbitalsodium(45mg/kg),recordedthemice’ssleeplatencyandsleepduration.②intraperitonealinjectionofpentobarbitalsodium(65mg/kg),untillossofrightingreflexinmiceaftertheintraperitonealinjectionofoxcamphor,recordedsleeptimeinmice.③Miceinjedtedintraperitoneallyoxcamphor,10minlater,putthemintotheYL
5、S-1Smulti-functionspontaneousactivitytester,andmadethemiceadaptedthenewenvironmentwithin2min,after5min,recordedthenumberofspontaneousactivityinmice.Results:①Theoxcamphorcansignificantlyprolongethemice’ssleeplatencyandshortsleepdurationatthresholddoseofpentobarbitalsodium.②Oxcamphorcansignific
6、antlyshortensleepingtimeabovethethresholddoseofpentobarbitalsodiuminmice,comparedwiththecontrolgroup,withastatisticallysignificantdifference(P<0.05orP<0.01).③Oxcamphorcansignificantlyincreasethenumberofspontaneousactivityinmice.Conclusion:Theoxcamphorhasthisfunctionthatitcanprolongesleeplaten
7、cy，shortensleepdurationandincreasethenumberofspontaneousactivityinmice.Keywords:oxcamphor;pentobarbitalsodium;sleep;spontaneousactivity氧化樟脑可兴奋延脑呼吸中枢和血管运动中枢,也可兴奋大脑皮层。氧化樟脑还具有兴奋心脏的功能,对于衰弱的心脏,可使其心脏收缩加强,恢复心脏的节律,增加每分钟的排出量,从而达到尽快恢复全身正常循环的作用[1]。另外有研究
