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1、授予单位代码10089学号或申请号20153282中国图书分类号R735.3HebeiMedicalUniversity硕士学位论文专业学位结肠癌新辅助化疗方案的选择研究生：张建清导师：刘津教授专业：外科学二级学院：河北医科大学第二医院2018年3月目录中文摘要··········································································································1英文摘要·················
2、·························································································2英文缩写··········································································································3综述结肠癌新辅助化疗方案的选择···········································
3、················5参考文献··········································································································18致谢···············································································································24个人简历···········
4、·······························································································25中文摘要结肠癌新辅助化疗方案的选择摘要结肠癌是我国常见的消化系统恶性肿瘤,发病率及致死率较高,手术早期切除是主要的治疗方式,但多数患者发现时已为晚期,手术切除困难,甚至失去根治性切除的机会,新辅助化疗的应用降低了肿瘤临床分期,提升了手术切除率,尤其与靶向药物的联合应用明显降低了术后复发及转移的风险。目的:为了能明确的了解新
5、辅助化疗的使用指征、治疗效果及如何针对不同患者选用合适的化疗方案。方法:本文通过系统阐述新辅助化疗中常规化疗药物的作用机制和常见不良反应发生原因,以及常用化疗方案在临床治疗中所获得的治疗效果,从而对新辅助化疗方案的选择提供指引方向。结论:新辅助化疗方案中FOLFOX方案、CapeOX方案、FOLFIRI方案均对结肠癌患者均有较好的疗效,尤其与靶向药物的联合应用，治疗效果更加显著，其中CapeOX方案的应用方式更加便捷，FOLFIRI方案对含奥沙利铂的化疗方案产生耐药的患者具有更高的疾病控制率。关键词：结直肠癌，新
6、辅助化疗，奥沙利铂，靶向药物，西妥昔单抗，贝伐珠单抗1英文摘要Selectionofneoadjuvantchemotherapyforcoloncancer.ABSTRACTColoncancerisacommonmalignanttumorofdigestivesysteminChina,morbidityandmortalityarehigh,andearlysurgicalresectionist-hemaintreatment.Butmostofthepatientswerefoundtohaveadv
7、anced,andthatishardtoresection,evenlostthechanceofradicalresection.Theapplicationofneoadjuvantchemotherapyreducedtheclinicalstageoftumor,andimprovedthesurgicalresectionrate，especiallywiththejointapplicationoftargeteddrugssignificantlyreducetheriskofpostoperat
8、iverecurrenceandmetastasis.Objective:tounderstandtheapplicationprinciplesofneoadjuvantchemotherapy,thetherapeuticeffectandhowtoselectappropriatechemotherapyfordifferentpatients.Method:bas
