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1、基于激光加热的玻璃基毛细管拉伸装置和实验研究ABSTRACTAtpresent,therearetwokindsofnanoporesfortheDNAsequencingtechnology:oneisthe
biologicalnanopire,andtheotheroneisthesolid-statenanopore.Comparedwithbiologicalnanopres,
solid-statenanoporeshavesomesignificantadvantagessuchashigherstrength,higherstabi
2、lityand
longerservicelife.Thenanoporesbasedonglasswithgoodphysicalpropertiesandlowcost,
comparingwithtraditionalnanoporesonthefilm,justneedsimplefacilities,andaremoresuitablefoe
industrialapplicationbesideslaboratory.Theglasscapillarytensionsystemisdesignedandmade.
Therearetwo
3、systemsbasedoninductionheatingandlaserheating.Relevantexperimentsaremade
tostudythechangelowoftheglasscapillaryintension.Doexperimentsbythesystembasedoninductionheatingtostudyeffectsoftensionrateand
heatingtemperatureoninnerandouterdiametersoftheglasscapillary.Theresultsshowth
4、atslower
tensionrateleadstosmallerdiameters,aswellasthehigherheatingtemperature.Theinnerdiameter
oftheglasscapillarystretchedbythissystemisassmallas500nm.Thereisafibrosisprobleminthe
stretchedglasscapillary.Tosolvethisproblem,theheatingrangemustbereduced.Thetensionsystembasedo
5、nlaserisdesignedtorealizetheheatingrangereduce.Thesystemis
composedbymechanicalstructureandsystemcontrol.Structuredesignmainlyincludesthelaser
heatingpartandtheultrasonicmotordrivingpart.Systemcontroldesignincludeshardwareand
software.Theprototypeisbuiltandtheprimaryexperiment
6、saremade.Stretchglasscapillarywith
thinporewalldirectlybythesystemonlaserheating.Onorthogonalexperimentaldesigntodo
experimentsandanalyzedata,andgettheoptimumparameters.Fortheglasscapillarywithgreater
wallthickness,asecond-stretchedexperimentalmethodisproposed.Withtheoverallex
7、perimentwith
singlefactor,effectsontheglasscapillaryatdifferentdutycycleisreached.Resultsshowthatthe
second-stretchedexperimentalmethodcanbeusedtomanufacturenanoporeswithsmallerinner
diameters,assmallas30nm.Keywords:DNAsequencingtechnology,ultrasonicmotordriving,laserheating,n
8、anoporesbasedonglass,orthogonalexperimentaldesignTheresearchp
