奥曲肽治疗化疗相关性腹泻最终

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1、Octreotideinchemotherapyinduceddiarrhoeaincolorectalcancer:areviewarticle奥曲肽治疗直肠癌患者化疗相关性诱发腹泻：综述Abstract摘要Background:Chemotherapy-induceddiarrhea(CID)iswellknownincancermanagement.Theriskisgreaterwhentheprimarycanceriscolorectal.ThearticleaimstowardsassessingtheroleofoctreotideinCID

2、throughanextensiveliteraturesearch.背景：化疗相关性诱发腹泻(CID)在癌症治疗中比较常见。特别是原发灶位于直肠的癌症则风险更大。本文旨在通过全面的文献检索评价奥曲肽治疗CID的作用。Methods：AftersearchingthroughPUBMED,MEDLINEandtheCochranelibrary,onlythosestudieswhichwerepublishedoverthelast20yearsinEnglishandwhereatleastthemajorityofthecohortwerecolore

3、ctalpatients,wereincluded.Tworandomizedtrials,fournon-randomizedstudiesandtwocase-seriespublicationswerethusconsidered.方法：检索PUBMED,MEDLIN和循证医学图书馆，选出最近20年用英文发表的、并且至少所选的主要观察队列为结肠病人的研究论文。符合条件的共有两项随机对照试验，四项非随机研究和两篇系列案例研究文献。Results:Itwasseeninboththerandomizedstudies,thatoctreotidehadmu

4、chbetteroutcomeascomparedtoloperamideintreatingsevereCID.Among88patientsfromthenon-randomizedstudieswithsevereCID,theprimarycancerwascolorectalin79patients.61patientshaddrug-resistantCID.Withinamaximumof96hours,octreotidereducedCIDby≥2gradesin91%of88patientsandin88.52%patientswithd

5、rug-resistantCID.结果：随机对照试验研究结果显示，奥曲肽治疗严重CID的疗效比咯哌丁胺好很多。非随机研究结果显示，88例严重CID病人中，原发是结肠癌的有79例。其中61例病人有CID抗药性。用奥曲肽治疗最长时间为96个小时后，88例严重CID病人中，抗药性降低的患者为91%，抗药性患者中88.52%患者的CID评分至少2级。Conclusion:OctreotideiseffectiveintreatingsevereCID,resistanttoothermodesoftreatment.Itisassociatedwithafewmin

6、oradverseeffects.Thoughexpensive,octreotidecouldbeconsideredasfirstlinemedicationinCIDofgrades3orabove.ItsuseinlowergradesofCIDwouldnotbecosteffective.结论：奥曲肽对其他治疗方式无效的严重CID患者有效，且不良反应较少。尽管价格比较昂贵，奥曲肽仍可考虑作为CID评分３级以上患者的一线药物。在低级别的CID治疗中，奥曲肽的作用并不是很大。Keywords:octreotide,chemotherapyinduce

7、ddiarrhoea,octreotideindiarrhoea.关键词：奥曲肽，化疗导致的腹泻，奥曲肽治疗腹泻Abbreviations缩写CID=Chemotherapyinduceddiarrhoea化疗相关性诱发腹泻5FU=5Fluorouracil5-氟尿嘧啶UFT=Uracil优福定NCI=NationalCancerInstitute国际肿瘤研究所NICE=NationalInstituteofClinicalExcellence国家临床优化研究所Introduction介绍Colorectalcanceristhesecondcommones

8、tcauseforcancerrelatedmort