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ID:23130918
大小:202.01 KB
页数:20页
时间:2018-11-04
《奥曲肽治疗化疗相关性腹泻最终》由会员上传分享,免费在线阅读,更多相关内容在应用文档-天天文库。
1、Octreotideinchemotherapyinduceddiarrhoeaincolorectalcancer:areviewarticle奥曲肽治疗直肠癌患者化疗相关性诱发腹泻:综述Abstract摘要Background:Chemotherapy-induceddiarrhea(CID)iswellknownincancermanagement.Theriskisgreaterwhentheprimarycanceriscolorectal.ThearticleaimstowardsassessingtheroleofoctreotideinCID
2、throughanextensiveliteraturesearch.背景:化疗相关性诱发腹泻(CID)在癌症治疗中比较常见。特别是原发灶位于直肠的癌症则风险更大。本文旨在通过全面的文献检索评价奥曲肽治疗CID的作用。Methods:AftersearchingthroughPUBMED,MEDLINEandtheCochranelibrary,onlythosestudieswhichwerepublishedoverthelast20yearsinEnglishandwhereatleastthemajorityofthecohortwerecolore
3、ctalpatients,wereincluded.Tworandomizedtrials,fournon-randomizedstudiesandtwocase-seriespublicationswerethusconsidered.方法:检索PUBMED,MEDLIN和循证医学图书馆,选出最近20年用英文发表的、并且至少所选的主要观察队列为结肠病人的研究论文。符合条件的共有两项随机对照试验,四项非随机研究和两篇系列案例研究文献。Results:Itwasseeninboththerandomizedstudies,thatoctreotidehadmu
4、chbetteroutcomeascomparedtoloperamideintreatingsevereCID.Among88patientsfromthenon-randomizedstudieswithsevereCID,theprimarycancerwascolorectalin79patients.61patientshaddrug-resistantCID.Withinamaximumof96hours,octreotidereducedCIDby≥2gradesin91%of88patientsandin88.52%patientswithd
5、rug-resistantCID.结果:随机对照试验研究结果显示,奥曲肽治疗严重CID的疗效比咯哌丁胺好很多。非随机研究结果显示,88例严重CID病人中,原发是结肠癌的有79例。其中61例病人有CID抗药性。用奥曲肽治疗最长时间为96个小时后,88例严重CID病人中,抗药性降低的患者为91%,抗药性患者中88.52%患者的CID评分至少2级。Conclusion:OctreotideiseffectiveintreatingsevereCID,resistanttoothermodesoftreatment.Itisassociatedwithafewmin
6、oradverseeffects.Thoughexpensive,octreotidecouldbeconsideredasfirstlinemedicationinCIDofgrades3orabove.ItsuseinlowergradesofCIDwouldnotbecosteffective.结论:奥曲肽对其他治疗方式无效的严重CID患者有效,且不良反应较少。尽管价格比较昂贵,奥曲肽仍可考虑作为CID评分3级以上患者的一线药物。在低级别的CID治疗中,奥曲肽的作用并不是很大。Keywords:octreotide,chemotherapyinduce
7、ddiarrhoea,octreotideindiarrhoea.关键词:奥曲肽,化疗导致的腹泻,奥曲肽治疗腹泻Abbreviations缩写CID=Chemotherapyinduceddiarrhoea化疗相关性诱发腹泻5FU=5Fluorouracil5-氟尿嘧啶UFT=Uracil优福定NCI=NationalCancerInstitute国际肿瘤研究所NICE=NationalInstituteofClinicalExcellence国家临床优化研究所Introduction介绍Colorectalcanceristhesecondcommones
8、tcauseforcancerrelatedmort
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