异甘草酸镁与复方甘草酸苷治疗慢性肝炎的疗效对比研究

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1、异甘草酸镁与复方甘草酸苷治疗慢性肝炎的疗效对比研究［摘要］目的对比分析慢性肝炎患者采用异甘草酸镁和复方甘草酸苷治疗后的临床效果。方法选择2014年9月〜2015年12月期间我院收治的103例慢性肝炎患者进行回顾性分析，按照治疗方法分为两组，研究组52例，采用异甘草酸镁治疗，对照组51例，采用复方甘草酸苷治疗，比较两组患者的临床疗效及肝功能。结果研究组的总有效率明显高于对照组，差异有统计学意义（P

2、、AST显著低于对照组，PA显著高于对照组，差异有统计学意义（P〈0.05）。结论异甘草酸镁及复方甘草酸苷在慢性肝炎的治疗方面均有较好的效果，但是异甘草酸镁与复方甘草酸苷比较更有优势,值得在临床推广应［关键词］肝炎；异甘草酸镁；复方甘草酸苷；病毒性肝炎酒精性脂肪性肝炎［中图分类号］R575.1［文献标识码］B［文章编号］1673-9701(2016)24-0104-03[Abstract]ObjectiveTocomparetheclinicaleffectinpatientswithchronichepatitistreatedwithisogl

3、ycyrrhizinatemagnesiumandcompoundglycyrrhizin.Methods103patientswithchronichepatitiswhowereselectedfromSeptember2014toDecember2015inourhospitalwereretrospectivelyanalyzed,allthepatientsweredividedintotwogroupsaccordingtothetreatmentmethods,thestudygroup(52cases)wasgivenisoglyc

4、yrrhizinatemagnesiumtreatment,andthecontrolgroup(51cases)wasgivencompoundglycyrrhizintreatment.Theclinicalefficacyandtheliverfunctionofthetwogroupswerecomparedbeforeandaftertreatment.ResultsThetotalefficiencyofthestudygroupwassignificantlyhigherthanthatofthecontrolgroup,thedif

5、ferencewasstatisticallysignificant(P<0.05)；Aftertreatment,ALT,TBIL,ASToftwogroupsweresignificantlylowerthanthosebeforetreatment,PAwassignificantlyhigherthanthosebeforetreatment,thedifferenceswerestatisticallysignificant(P〈0.05)；ALT,TBIL,ASTofthestudygroupaftertreatmentweresign

6、ificantlowerthanthatofthecontrolgroup,PAofthestudygroupaftertreatmentwassignificanthigherthanthatofthecontrolgroup,thedifferenceswerestatisticallysignificant(P<0.05).ConclusionEffectofisoglycyrrhizinateandmagnesiumcompoundglycyrrhizininthetreatmentofchronichepatitisisbetter,bu

7、tisoglycyrrhizinatemagnesiumcompoundglycyrrhizincomparativeadvantage,itcanbeappliedinclinicalpractice.[Keywords]Hepatitis；Isoglycyrrhizinatemagnesium；Compoundglycyrrhizin;Viralhepatitis；Alcoholicsteatohepatitis慢性肝炎是我国临床常见病、多发病。引发慢性肝炎的原较多，包括病毒感染、长期饮酒、药物等，患者多以腹胀、恶心、呕吐、黄疽等为主要临床表现

8、，慢性肝炎分为轻、中、重度，病情越严重的患者预后越差，慢性肝炎对患者的身体健康造成严重影响，降低患者的生活质量［1］。近年