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1、吸烟、饮酒与原发性肝癌发病年龄关系研究吴燕陈陶阳孙燕陆培新王金兵张启南(江苏省启东人民医院226200)【摘要】目的:探究吸烟、饮酒与原发性肝癌发病年龄的相关性研究。方法:对549例原发性肝癌患者进行系统性分析,按照其是否吸烟、饮酒分为4组,即吸烟饮酒组、吸烟不饮酒组、饮酒不吸烟组以及既不吸烟也不饮酒组,分别用A、B、C、D代表各组,对比分析四组患者的平均发病年龄情况。结果:A组患者的平均发病年龄为(41.2&plUsmn;8.4)岁,B组患者的平均发病年龄为(47.6±7.9)岁,C组患者的
2、平均发病年龄为(48.3±8.4)岁,D组患者的平均发病年龄为(57.4&Plusmn;6.9)岁,A组患者的发病年龄明显低于其余三组,且存在差异性(P<0.05),与D组患者的差异性更为明显(P<0.01),D组患者的发病年龄最晚。结论:饮酒是原发性肝癌密发病的高度危险因素,长时期的饮酒会使原发性肝癌的发病趋向年轻化,单独的吸烟对于原发性肝癌的发病年龄无明显影响,但吸烟及饮酒同时存在时,原发性肝癌的发病年龄明显年轻化。【关键词】吸烟饮酒原发性肝癌【中图分类号】R735.7【文献标
3、识码】A【文章编号】1672-5085(2014)18-0015-01Researchontherelationshipbetweensmokinganddrinkingages,andprimarylivercancer【Abstract】Objective:Toexplorethesmoking,drinkingagecorrelationwithprimarylivercancer.Methods:549casesofprimarylivercancerpatientsweresystematical
4、lyanalyzedaccordingtotheirsmokinganddrinkingweredividedintofourgroups,namelysmokinganddrinkinggroup,thegroupofsmokerswithoutdrinking,drinkingandsmokinggroupdoesneithersmokingnordrinkinggroup,respectivelywitha,B,C,Donbehalfofthegroup,theaverageageofonsetcas
5、escomparativeanalysisofthefourgroupsofpatients.Results:ThemeanageofonsetforpatientsingroupA(41.2±8.4)years,theaverageageofonsetgroupBpatientswas(47.6±7.9)years,meanageofpatientsingroupCwas(48.3±8.4)yearsold,Dpatientstheaverageagewas(57
6、.4±6.9)yearsofage,ageofpatientsingroupAwassignificantlylowerthantheotherthreegroups,andtherearedifferences(P<0.05),andDgroupsweremoresignificantdifferences(P<0.01),ageofpatientsingroupDatthelatest.Conclusion:Drinkingisahighriskfactorinthepatho
7、genesisofhepatocellularcarcinomadense,theincidenceofprimarylivercancercausesprolongeddrinkingofgettingyounger,theageofonsetofsmokingalonehadnosignificantimpactonprimarylivercancer,butsmokinganddrinkingAtthesametimethepresenceoftheageofonsetofprimaryliverca
8、ncerweresignificantlyyounger.【Keywords】smokingdrinkingprimarylivercancer原发性肝癌是全球第6位、中国第三位的常见癌症;中国14个肿瘤登记处合计的肝癌发病率为30.3/10万,男女比例为2.85:1[1]。0前,众多的研宄人员认为吸烟、饮酒与原发性肝癌的发病存在密切相关性,为此,本文对肝癌前瞻研宄队列14年随防549例原发性肝癌患者的资料进行了