雀斑与遗传课件

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1、雀斑的遗传学研究简介OutlineBackgroundsAbstractandIntroductionMaterialsandMethodsResultsandDiscussionBackgroundsFrecklesareclustersofconcentratedmelaninwhicharemostoftenvisibleonpeoplewithafaircomplexion.Afreckleisalsocalledan"ephelis".遗传性对称性色素异常症和雀斑的临床特点及遗传方式的研

2、究安徽医科大学林国书ChinesescientistslocalizefrecklegeneChinesescientistshavefoundthatfreckles,anuisanceformanypeople,arecausedbycertaingeneticvariations.Prof.Zhangandhiscolleaguesusedstate-of-the-artgenomescanningtechnologiestoanalyzethesamplesbeforetheycameto

3、theconclusion.Freckleshavelongbeenanuisanceforbeauty-seekinggirls.[filephoto]—ChinadailyUpdated:2004-04-1109:55Themelanocortin-1-receptorgeneisthemajorfrecklegeneThehighprevalenceofMC1Rgenevariantsandephelidesandthestrongassociationbetweenthesevariabl

4、esindicatethattheMC1RgenecontributeslargelytotheetiologyofephelidesandsuggeststheMC1Rgenetobethemajorephelidesgene.AbstractThepurposeofthisstudywastoinvestigatetherelationshipbetweenMC1Rgenevariantsandephelides.AbstractInalargecase-controlstudy,patien

5、tswithmelanomaandnon-melanomaskincancerandsubjectswithoutahistoryofskincancerwerestudied.TheentirecodingsequenceoftheMC1Rgenewasanalyzedbyfollowedbysequenceanalyses.single-strandconformationpolymorphismanalysisAbstractAsnearlyallindividualswithephelid

6、eswerecarriersofatleastoneMC1Rgenevariant,ourdatasuggestthatMC1Rgenevariantsaretodevelopephelides.necessaryAbstractIntroductionEphelidesaresmallpigmentedspotsoftheskincommonlyoccuringintheCaucasianpopulation,morefrequentlyinfair-skinnedindividualswith

7、redorlight-blondhairRussiantennisbeautyMariaSharapova,CaucasianIntroductionThemelanocortin-1-receptor(MC1R)geneplaysanimportantroleinthegeneticsofhumanpigmentationThehumanMC1Rgene,localizedonchromosome16q24.3,ishighlypolymorphicinthewhitepopulationand

8、MC1RgenevariantshavebeenfoundtobeassociatedwithfairskinandredhairIntroductionMC1Rgenevariantsareassociatedwithanincreasedriskofcutaneousmalignantmelanomaandnon-melanomaskincancer.Thisdiseaseisastrongriskindicatorformelanomaandnon-melanomaskinc