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ID:21035141
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时间:2018-10-19
《活性维生素d3对维持性血透患者hepcindin影响的研究分析》由会员上传分享,免费在线阅读,更多相关内容在工程资料-天天文库。
1、活性维生素D3对维持性血透患者hepcindin影响的研究分析湖南省委底市中心医院肾内科湖南委底417000摘要:目的:探讨活性维生素D3对维持性血透(MHD)患者铁调素(hepcindin)表达的影响以及对不宁腿综合征、贫血的影响。方法:将38例维持性血透并发不宁腿综合征的患者随机分成治疗组和对照组,治疗组在对照组治疗的基础上加用合理的活性维生素D3进行治疗。结果:治疗组血清iPTH、hsCRP、HBG、IL一6、hepcidin、铁治疗前后比较P<0.05;治疗后治疗组与对照组比较P<0.05。血清hepcidin的表达与血清铁、血红蛋白、hsCRP、IL
2、—6的表达相关,并且与血清铁、血红蛋白呈负相关,与血清hsCRP、IL一6的表达呈正相关,且不宁腿综合征的临床症状明显减轻甚至消失。结论:活性维生素D3可抑制维持性血透患者hepcindin的表达,改善维持性血透患者的微炎症环境,改善贫血和不宁腿综合征的症状,为临床难治性肾性贫血提供新的治疗思路,为寻找新的治疗靶点及药物提供基础,改善了维持性血透患者的生存质量和生活质量,减少其住院率、输血率和死亡率,减少血液资源的浪费,减轻患者家庭经济负担,其有良好的社会效益及经济效益。关键词:活性维生素D3;维持性血透;铁调素;血清铁;血红蛋白Abstract:Object
3、ive:ItistoexploretheeffectsofactivevitaminD3onlevelsofhepcindininpatientswithmaintenancehemodialysis(MHD),onrestlesslegssyndromeandanemia.Methods:38MHDpatientswithrestlesslegssyndromewererandomlydividedintotwogroups:treatmentgroupandcontrolgroup.Treatmentgroupweretreatedwithactivevi
4、taminD3inadditiontotheroutinemedicinetreatmenttothecontrolgroup.Results:ThereweresignificantdifferencesinlevelsofserumiPTH,hsCRP,HGB,IL—6,hepcidinandserumironaftertreatmentcomparedwiththosebeforetreatmentintreatmentgroup(P<0.05).Aftertreatment,therewerealsoapparentdifferencesinle
5、velsofserumiPTH,hsCRP,HGB,IL—6,hepcidinandserumironbetweentreatmentgroupandcontrolgroup(P<0.05).Thelevelofserumhepcidiniscorrelatedwiththelevelofserumiron,HGB,hsCRP,IL—6.ItisrevealedthatthelevelofserumhepcidinispositivelycorrelatedwiththelevelofhsCRPandIL—6whilenegativelywiththat
6、ofserumironandHGB.ltisalsofoundedthatthesymptomsofrestlesslegssyndromewereobviouslyrelievedorevendisappeared.Conclusions:ActivevitaminD3candecreasethelevelofhepcindinandthusimprovethemicro-inflammationinMHDpatients.ltcanalsoimprovethesymptomofanemiaandrestlesslegssyndrome,whichprovi
7、desanewideaforthetreatmentofrefractoryrenalanemiaandlaysagoodfoundationforseekingnewtherapeutictargetsanddrugsforthetreatmentofMHDpatients.Therefore,itcanprolongsurvivalandimprovequalityoflifeofMHDpatientsbydecreasingrateofhospitalization,bloodtransfusionanddeath.Besides,itcanalsore
8、ducethewasteofblood
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