PROVE IT研究PPT课件.ppt

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1、PravastatinorAtorvastatinEvaluationandInfectionTherapy(PROVEIT):DesignCannonCPetal.NEnglJMed2004;350:1495-1504.4162patientshospitalizedforACSwithinprevious10days,TC240mg/dL(200mg/dLifonlipidRx)Randomizedtopravastatin40mg(standardtherapy)oratorvastatin8

2、0mg(intensivetherapy)Primaryendpoint:compositeofdeath,MI,unstableanginarequiringrehospitalization,revascularization(atleast30daysafterrandomization),andstrokeFollow-up:18–36months(mean,24)PROVEIT:BaselineCharacteristicsMean±SD,n(%),ormedian(interquartile

3、range)Pravastatin40mg(n=2063)Atorvastatin80mg(n=2099)Age,yr58.3±11.358.1±11.2Malesex1617(78.4)1634(77.8)Whiterace1865(90.4)1911(91.0)Diabetes361(17.5)373(17.8)Hypertension1014(49.2)1077(51.3)Currentsmoker766(37.1)763(36.4)Peripheralarterialdisease[p=.03]

4、136(6.6)105(5.0)Totalcholesterol,mg/dL180(158–202)181(160–205)LDL-C,mg/dL106(87–127)106(89–128)HDL-C,mg/dL39(33–46)38(32–46)Triglycerides,mg/dL154(115–207)158(119–214)Priorstatintherapy514(24.9)535(25.5)CannonCPetal.NEnglJMed2004;350:1495-1504.Adaptedwit

5、hpermission.Copyright©2004MassachusettsMedicalSociety.Allrightsreserved.PROVEIT:LipidandCRPChangesChangefromBaseline,%Pravastatin40mgAtorvastatin80mgp<.001CannonCPetal.NEnglJMed2004;350:1495-1504.CRPHDL-CLDL-Cp<.001p<.001–10.4–41.58.16.5–82.9–89.4PROVEIT

6、:LDL-CAchievedMedianLDL-C,mg/dL1069562BaselineCannonCPetal.NEnglJMed2004;350:1495-1504.Pravastatin40mgAtorvastatin80mgp<.001PROVEIT:EffectonCRPMedianCRP,mg/L12.32.11.3BaselineCannonCPetal.NEnglJMed2004;350:1495-1504.Pravastatin40mgAtorvastatin80mgp<.

7、001Pravastatin40mgAtorvastatin80mgPROVEIT:PrimaryandSecondaryEndpointsKaplan–MeierEventRate,%CannonCPetal.NEnglJMed2004;350:1495-1504.14%,p=.02916%,p=.00526.322.422.319.71°endpoint:death,MI,unstableangina,revascularization,stroke2°endpoint:CHDdeath,M

8、I,revascularizationReductioninDeathorMajorCardiovascularEventwithIntensiveStatinTherapyDeathorMajorCardiovascularEvent,%20632099No.atRiskPravastatinAtorvastatin036912151821242730MonthsofFollow-up16881736153615911423148581