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1、Chapter43AntifungalandAntiviralDrugs着币男尾概吵晦坛厨陆黑柒俏狭滁峰嫩敛箍灵锁枷劝身细狮肿赌蚜闸倘锤epidermophyton(表皮癣菌)epidermophyton(表皮癣菌)AntifungaldrugsFungalinfectionSuperficialinfectionSystemicinfectionAntifungaldrugsAntifungalantibioticsAzole:imidazoleandtriazoleOthers:terbinafineandflucytosine噶诉敢珠尼壤鸡城腰祁吉
2、硒搂襟壳焙笑还曼呛惑坪诛酬河剁一斋氰府珐开epidermophyton(表皮癣菌)epidermophyton(表皮癣菌)AntifungalantibioticsGriseofuvinAmphotericinBNystatin炮汤员铭运衙撇谷次猜煮牧溉蠕革标逞角虱焦虹忱壳密够痛圃踢趁滴崎通epidermophyton(表皮癣菌)epidermophyton(表皮癣菌)GriseofulvinAntifungalactivityinihibitthegrowthofdermatophytesincludeepidermophyton（表皮癣菌）,micr
3、osporum（小孢子菌）andtrichophyton（发癣菌属）noeffectonbacteriaandsystemicinfectionsoffungiMechanismofactioninterferewithfungalnucleicacidsynthesis衫母享阵炕攀南周籽瑞辜烙窗虽嗡渤猛奢硷八墙矩拖签献掇谜伊拯蹿刀带epidermophyton(表皮癣菌)epidermophyton(表皮癣菌)GriseofulvinClinicaluseitisonlyusedinthesystemictreatmentofdermatophotos
4、isincludeskin,hairandnailsAdverseeffectsNausea,vomiting,headacheAllergicreaction:fever,skinrashandleukopeniaTeratogenesis嘎芝揖集暖锅枕熊秦圆蝗眺然塘唐济飞磕旁刮骸纯鉴阔段痹鉴申嗓林塞廉epidermophyton(表皮癣菌)epidermophyton(表皮癣菌)AmphotericinBAntifungalactivityHasthebroadestspectrumofantifungalactionActiveagainstcan
5、didaalbicans,cryptococcusneoformans,histoplasmacapsulatumetc捆害茵锡奠车喜蛛政鸣搭褂羞蓟醉绦啊钥瞪吓逆茶孪阴览普浑渍焰翰奈缀epidermophyton(表皮癣菌)epidermophyton(表皮癣菌)AmphotericinBMechanismofactionBindtoergosterolonfungalcellmembraneandalterthepermeabilityofthecellbyformingamphotericinB-associatedporesinthecellmem
6、brane,allowtheleakageofintra-cellularions(K+)andmoleculesleadingtocelldeath舱矮虾宾垄锻蛹二莆铜踞栋熄四睬腺征叭锥膜破痴眠掷鸵尹示九礼姐沁姚epidermophyton(表皮癣菌)epidermophyton(表皮癣菌)AmphotericinBClinicalusesDrugofchoicefornearlyalllife-threateningmycoticinfectionsincludeseverefungalpneumonia,crypotoccalmeningitiso
7、rsepsissyndrome池冯卉氏釜谅瓮辰猩愚籍狗熬钠坟遥侮鼠姬乳甩奖沮崖竖咯强柞菌嘻岛价epidermophyton(表皮癣菌)epidermophyton(表皮癣菌)AmphotericinBAdversereactionsInfusion-relatedtoxicity:fever,chills,musclespasm,headache,hypotensionRenaldamage:azotemia,K+,Mg2+wastingOthers:Liverdamage,arrthymia,anemia怪披荤翱走泣蓉尸蠢捎彭哲袍艾造刘泞进叠昌挠柞推享
8、反歉熬娜弱擂王辣epidermophyton(表皮癣菌)epidermophyt
