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1、特发性间质性肺炎新分类及治疗进展中国医学科学院北京协和医院呼吸科徐作军内容特发性间质性肺炎的新分类实用临床分类分子生物学标记物检测IPF治疗进展内容特发性间质性肺炎的新分类实用临床分类分子生物学标记物检测IPF治疗进展DiffuseParenchymalLungDiseases/InterstitialLungDisease(DPLD/ILD)已知原因：药物、CTD、粉尘、放射等肉芽肿性疾病：结节病、外源性过敏性肺炎等其他：LAM、PLCH、EP等特发性间质性肺炎(IIP)ATS/ERSstatement:AJRCCM2002;165:277特发性肺纤维化（IP
2、F/UIP）非特异性间质性肺炎（NSIP）隐原性机化性肺炎（COP）淋巴细胞间质性肺炎（LIP）脱屑型间质性肺炎（DIP）急性间质性肺炎（AIP）呼吸性细支气管炎伴间质性肺病（RBILD）ScheduleofIIPclassificationprojectMay,2010–ATS/NewOrleansSeptember,2010–ERS/BarcelonaJanuary,2011–Writingcommittee,NYCApril,2011–Modena,ItalyMay,2011–ATS/DenverSeptember,2011–ERS/AmsterdamJa
3、nuary,2012–Writingcommittee,NYCApril,2012–FinaldraftsubmittedSeptember,2012–SubmissionofrevisionMembersoftheATS/ERSCommitteeonIIPWilliamTravis,MD.(Chair)TalmadgeE.King,Jr.,MD,(Co-Chair)UlrichCostabel,(Co-Chair)AtholWells,(Co-Chair)PULMONARY(17+4)JayH.Ryu,USA(SubcommitteeChair)JurgenB
4、ehr,GermanyDemosthenesBouros,GreeceKevinBrown,USAHaroldCollard,USACarlosRobaloCordeiro,PortugalVincentCottin,FranceMarjoleinDrent,TheNetherlandsJimEgan,IrelandKevinFlaherty,USATravis,WDYoshikazuInoue,JapanDongSoonKim,KoreaFernandoMartinez,USAGaneshRaghu,USALucaRicheldi,ItalyDominique
5、Valeyre,FranceRADIOLOGYDavidHansell,UnitedKingdom(Subcommitteeco-chair)DavidLynch,USA(Subcommitteeco-chair)TakeshiJohkoh,JapanNicolaSverzellati,ItalyPATHOLOGYAndrewNicholson,UnitedKingdom(SubcommitteeChair)ThomasV.Colby,USAMasanoriKitaichi,JapanJeffreyMyers,USAMOLECULARBIOLOGYMoisesS
6、elman,Mexico(Subcommitteechair)BrunoCrestani,FranceCoryHogaboam,USAJamesLoyd,USAEVIDENCEBASEDANALYSISChristopherRyerson,Canada(Subcommitteechair)JeffreySwigris,USAREFERENCELIBRARIANSRosalindF.Dudden,M.L.S.ShandraProtzko,M.L.S.Finalface-to-facemeeting,Modena,June2008WordCount:3489Abst
7、ractwordcount:248Tables:4Figures:8Supplementalmaterials:2Tablesand1AppendixReference:159新分类方案与2002年IIP专家共识的区别（1）明确了特发性NSIP（iNSIP）是一种独立的临床病理的类型，其临床过程呈高度异质性；（2）收集了更多的吸烟相关性间质性肺病的信息，特别是肺气肿合并肺纤维化（CEPF）；（3）认为IPF的自然病程多样性，可以长期稳定，可以快速进行性进展，可以在病程中出现急性加重；AJRCCM2011;183:788-824(modified)DISEASEP
8、ROGRESSIONTI
