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时间:2018-09-15
《实验性近视眼后极部巩膜胶原和蛋白多糖水平的改变》由会员上传分享,免费在线阅读,更多相关内容在学术论文-天天文库。
1、万方数据InternationalJournalofOphthalmology,V01.6,No.3.Jun.2006Teh029-82245172Email:IJO.2000@163.com、】l嘲唧Uo.魏·实验研究·实验性近视眼后极部巩膜胶原和蛋白多糖水平的改变谭佳,刘双珍,邓志宏,魏欣,谭星平ChangesofcollagenanddecorinlevelintheposteriorscleraoftheexperimentalmyopiaJiaTan,Shuang-ZhenLiu,Zhi-HongDeng,XinWei,Xing-PingTanDepartme
2、ntofOphthalmology.XiangyaHospitalofCentralSouthU-niversity。Changsha410∞8。HIln盎][1Province,ChinaCorrespondenceto:Shuan譬一ZhenLiu.DepartmentofOphthalmolo—gY,XiangyaHospitalofCentralSouthUniversity,Changsha410008,HunanProvince.China.1iushzhxy@163.comReceived:2貘撼—03一llAccepted:2麓6尚4—25Abstrac
3、t‘A王M:blnvestigatethechangesofcollagenanddecodnlevelintheposteriorscleraofGuineaPig钟esinducedbyform—deprivationandtheirassociationwiththepathogenesisofmammalmyopia。·M日拜CIDS:TwogroupsOfGuineaPigs,with10animalseach,wereincludedinthestudy.Animalsinthemonocu-lar-deprived(HD)groupweresubjecte
4、dto2wkofformdepri-vaUon,andthoseintheMD/recoverygroupweretreatedthesamewayfollowedbylwkofrecovery。两m’deprivationbymonoculareyeshadewasintroducedbetween2and3wkofageinalIanimals。Thecontralateral,untreatedeyesoftheanimalsservedasInterocularcontrols。Therefractionandtheaxialeyelenothofallanim
5、alsweremeasuredatthebegin-ningandtheendofthetreatmentperiod.AIIanimalswereSacnficedandeyesenucleatedattheendofstudy。Thepos-teriorsclerawasdissectedfromtheeyeandtheexpressionsofdecorincoreproteinmRNAandcollagenlmRNAwereas-sayedby附卜PCR。ThedatawasanalyzedbymeansofpaIiredt-testandanalysisofv
6、ariance(ANOVA)。。RESULTS:ThereweresignificantdifferencesintherelativelevelofcollagenIanddecorincoreproteinmRNAbetweentheMDeyesandinterocularcontrols(P<0.0s)whichwereal-soseenbetweentherecoveredeyesandinterocularcontrols。。CONCLUSION:CollagenIanddecorinlevelintheposteriorscleraofGuineaPigey
7、esdecreasesignificantlyuponformde。pnvation,andcanberestoredbyrecovery。Itissuggestedthat囊eybothmightbeinvolvedinthepathogenesisofmpopia.作者单位:(410008)中国湖南省长沙市,中南大学湘雅医院跟科终者笾分:谭佳,女,在读薄±研究生,磅究方囊:矮燕、斜巍及弱视。通讯作者:刘双珍.1iushzhxy@163.com收藕t3期:2006-03一ll修回日期:2006—04—25’KEYWORDS:Guinea
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