膜泡运输的结构基础ppt课件

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1、Figure13-3MolecularBiologyoftheCell(©GarlandScience2008)IntracellularVesicularTrafficLocationofmicrotubule-associatedproteinsMAP1AMAP1BMAP2AMAP2B(tau)MAP1AMAP1BMAP2CtauDendriteAxonMajormicrotubule-associatedproteinsThecellstransfectedwithtautypeL4Theimport

2、anceofMAPsforneuriteformationCross-sectionelectronmicrographsofMAP-inducedprocessesinSf9cellsMAP2MAP2CtauMAP2invitroTauinvitorOrganizationofMTbundlesbyMAPs.SpacingofMTsdependsonMAPsInsectcellexpressingMAP2InsectcellexpressingtauJ.Chenetal.Nature.1992Cytosk

3、eletalarchitectureAXONDENDRITEKinesinandDyneinMicrotubule-basedtransportandintracellulartraffickingpathwaysHirokawaetal.,2009Haradaetal.,JCB,1998GolgivesiculationandlysosomedispersionincellslackingcytoplasmicdyneinMolecularmotor-kinesinStructuresofN-kinesi

4、ns,M-kinesinsandC-kinesinsPhylogenicanalysisofallKIFsexpressedinmouse/humans,D.melanogaster,C.elegans,andS.cerevisiae.ThestructureandphylogenyofmajormousekinesinsHirokawaetal.,2009QWangetal.,CellRes.2010PrincipalmembersofKIFsobservedbylowanglerotaryshadow

5、ingHirokawaetal.,2005KIFsbindtocargoesthroughadaptororscaffoldingproteincomplexesHirokawaetal.,2005Tanakaetal.,Cell.93:1174-1158.1998KIF3isfunctionallydiversefamilyofmotorLeft/rightdeterminationRetinitispigmentosaPolycystickidneydisease(PKD)Tumoursuppresso

6、radenomatouspolyposiscoli(APC)FodrinSmallGTP-bindingproteindissociationfactorSmgGDSPAR-3NonakaS.etal.,1998Cell,95:829–837Kartagener综合征又称支气管扩张-鼻旁窦炎-内脏转位综合征TheKIF3MotorTransportsN-cadherinandOrganizestheDevelopingNeuroepitheliumHypertrophyandinvadingtumor-

7、likerosettephenotypeofkap3cKOmouseKAP3-deficientleadstomalignanttransformationofneuroepitheliumN-cadherinandbeta-cateninlevelsarereducedfromcellperpheryincKObrainImpairedCa2+-dependentcelladhesioninkap3-/-MEFs