超声声学造影评价颈动脉粥样硬化斑块新生血管形成及稳定性（英文）

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1、CorrelationofCarotidPlaqueNeovascularizationDetectedbyContrast-EnhancedUltrasoundImagingWithClinicalSymptomsYou-BinDeng,MD,邓又斌TongjiHospital,HuazhongUniversityofScienceandTechnology,Wuhan,China武汉同济医院MechanismsofvesselwallneovascularizationinatherosclerosisDoyleBetal.JACC2007;49:2073Possiblero

2、lesformicrovesselsindiseaseprogressionincludethesupplyofcellularandsolublelesioncomponents,enhancementofintraplaquegasexchange,anddeliveryofmetabolicsubstratestotheplaquecore.DoyleBetal.JACC2007;49:2073NeovascularizationinStableandUnstableCoronaryPlaquesKolodgieFDetal.JACC2007;49:2093Plaquene

3、ovascularizationandclinicalsymptomsFleinerMetal.Circulation2004;110:2843Numberofmicrovesselsidentifiedfromplaquesofsymptomaticandasymptomaticpatients.McCarthyMJetal.JVascSurg1999;30:261VesselDensityatHistologyAccordingtoPlaqueContrast-AgentEnhancementColiSetal.JACC2008;52:223Vulnerablepatient

4、shavevulnerableplaquesPlaqueneovascularizationistheremarkablyconsistentfeatureofvulnerableplaqueincerebrovascularpatientsContrast-enhancedcarotidultrasoundimagingispromisingandmayservetodetecttheneovascularizationwithintheatheroscleroticplaqueinvivo.Carotidplaquecontrast-agentenhancementwiths

5、onographicagentcorrelateswithhistologicaldensityofneovesselswithinthecarotidplaqueTheassociationbetweenthecarotidplaqueenhancementwithcontrastagentmicrobubblesandclinicalsymptomsisnotfullyunderstood.StudyPopulation研究方法GELog9超声诊断仪9L探头：频率为6MHz机械指数：0.13104例患者快速静脉注射SonoVue1.5ml实时观察颈动脉腔及斑块内造影剂显影情况

6、Grade1:noenhancementwithintheplaqueorenhancementconfinedtoplaqueadventitialsideand/orshoulderGrade2:enhancementreachingplaquecore/orextensivecontrastagentenhancementthroughouttheplaque.GradingofContrast-AgentEnhancementbyVisualInterpretationGradingofContrast-AgentEnhancementbyQuantitativeAnal

7、ysisEnhancedintensityintheplaqueRatiooftheenhancedintensityintheplaquetothatinthecarotidarterylumenReceiverOperatingCharacteristicCurveAnalysisThesensitivityandspecificityforenhancedintensityintheplaque(cutoffvalue:10.0dB)were74%and62%,respec