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1、718周期夫精宫腔内人工授精临床因素分析海南医学院2006,12(4):310—313310JournalofHainanMedicalCollege718周期夫精宫腔内人工授精临床因素分析卢伟英,刘西茹,黄元华,徐雯,云日明,潘曼玲(1.海南医学院附属医院生殖医学中心,海南海口570102;2.重庆医科大学附属第一医院生殖医学中心,重庆400016)[摘要】目的:探讨影响夫精宫腔内人工授精(intrauterineinseminatio,IUI)成功率的各种临床因素.方法:回顾性分析526例患者进行7l8周期的IUI.对患者年龄,自然周期或超排卵周期,IU1次数,IUI
2、活性精子数量,输卵管条件,子宫内膜厚度与妊娠率的关系进行分析.结果:7l8周期的IUI中妊娠109周期,其中双胎妊娠率9.2%,三胎妊娠率为2.8%,流产率为22.2%,每周期临床妊娠率为l5.2%.自然周期或超排卵周期,单侧或双侧输卵管通畅病人间,妊娠率无显着性差异(0.05).就女方年龄,<30岁,30—40岁和>40岁妊娠率分别为l7.24%,l4.40%和3.22%,年龄越大受孕率越低,>40岁组妊娠率明显低于前两组(19<0,05)).第3次IUI的妊娠率明显高于第2次IUI(妊娠率分别为25.0o%,l0.39%,P<0.05).
3、当IUI活性精子数量低于lx10时,妊娠率为3.33%.明显低于活性精子数为l~lOxlO,10—50x10,和>50x10组(妊娠率分别为l5.82%,l6.67%和27.27%,P<0.05).LH峰或注射HCG时,子宫内膜厚度<7mm和>16mm时,妊娠率分别为7.14%和3.23%,明显低于7—12mm和l3—16mm组(妊娠率为l6.86%和l4.18%,P<O.05).结论:IUI中女方的年龄,IUI活性精子数量和子宫内膜厚度是影响IUI妊娠率的直接因素.[关键词】妊娠;精子计数;子宫内膜;年龄因素;授精,人工[中图分类号】R32
4、1.3[文献标识码】A[文章编号】1007—1237(2006)04—0310—04Analysisofclinicalfactorsaffectingpregnancyrateofintrauterinea~ificialinsemi-nationfrOm718cyclesLUWei—ying,LIUXi-Ru,HuangYuan-hua,eta1.(MedicalCenterofReproduction,AffiliatedHospitalofHainanMedicalCollege,HainanHaikou570102,P.R.China)[ABSTRACT]Obj
5、ective:Tostudythevariousclinicalfactorsaffectingthepregnancyrateoftheintrauterineartificialinsemination(IUI)withhusbandsperm.Methods:718cyclesof526patientswithIU1wereanalyzedretrospectively.Thestudyfocusedontherelationshipsoftheageoffemalepatient,naturalandstimulantcycles,timesofIUI,thenu
6、mbersofthemovingsperm,theoviductconditionandendometriumthicknesswiththepregnancyrato.Results:Thereweretotally109pregnancycyclesin718cyclesofIUI,ofthesetwinpregnancyratewas9.2%,tripletpregnancyratewas2.8%,miscarriageratewas22.2%,andclinicalpregnancyrate(CPR)percyclewas15.2%.Therewasnosigni
7、ficantdifferenceinthepregnancyrate(P>0.05)betweennaturalandstimulantcycles.singleanddoubleunobstructedoviduct.Whenthefemalepatientsweredividedintothreegroups(age<=30,age30<age<=40,andage>40),theirpregnancyrateswere17.24%,14.40%and3.22%respectively,and
