β┐连环蛋白在原发性肝细胞癌中的表达及其临床意义

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1、¦Â©´Á¬»·µ°°×ÔÚÔ·¢ÐÔ¸Îϸ°û°©Öеıí´ï¼°ÆäÁÙ´²ÒâÒ塾¹Ø¼ü´Ê¡¿,°©¹Ø¼ü´Ê:°©£¬¸Îϸ°û;¦Â-Á¬»·µ°°×;ÃâÒß×éÖ¯»¯Ñ§ÕªÒª:Ä¿µÄÑо¿¦Â-Á¬»·µ°°×ÔÚÔ·¢ÐÔ¸Îϸ°û°©Öеıí´ï¼°ÆäÓëÔ·¢ÐÔ¸Îϸ°û°©·Ö»¯¡¢ÇÖϮתÒƺÍÔ¤ºóµÄ¹Øϵ.·½·¨Ó¦ÓÃÃâÒß×éÖ¯»¯Ñ§·½·¨¶Ô63ÀýÔ·¢ÐÔ¸Îϸ°û°©Ê¯À¯°üÂñ±ê±¾½øÐЦÂ-Á¬»·µ°°×°ë¶¨Á¿¼ì²â.½á¹ûÓÐ49Àý£¨78%£©Ô

2、·¢ÐÔ¸Îϸ°û°©¦Â-Á¬»·µ°°×ÑôÐÔ±í´ï£¬µÍ·Ö»¯°©µÄ¦Â-Á¬»·µ°°×ÑôÐÔÂÊÃ÷ÏÔ¸ßÓڸ߷ֻ¯°©£¨P<0.05£©.¦Â-Á¬»·µ°°×ÑôÐÔ±í´ïÂÊÔÚAFP¸ß±í´ï¸Î°©×é¸ßÓÚAFPµÍ±í´ï×飨P<0.05£©.¦Â-Á¬»·µ°°×ÑôÐÔ±í´ïÂÊÔÚÓÐÁܰͽáתÒƸΰ©×éÖ¯¸ßÓÚÎÞÁܰͽáתÒÆ×飨P<0.05£©.¦Â-Á¬»·µ°°×ÑôÐÔ±í´ï»¼Õß2aÉú´æÂÊ£¨11%£©ÏÔÖøµÍÓÚÒõÐÔ±í´ïÕߣ¨32%£

3、¬P<0.05£©.½áÂÛ¦Â-Á¬»·µ°°×±í´ïÓë¸Î°©×éÖ¯µÄ·Ö»¯³Ì¶È¡¢ÓÐÎÞÁܰͽáתÒÆ¡¢»¼ÕßµÄAFPˮƽ³ÊÕýÏà¹Ø£¬¦Â-Á¬»·µ°°×±í´ïÓ뻼ÕßÔ¤ºóÏà¹Ø£¬¿ÉÒÔ×÷ΪÅжÏÔ·¢ÐÔ¸Îϸ°û°©Ô¤ºóµÄÉúÎïѧָ±ê.¡¡¡¡¡¡Keywords:carcinoma£¬hepatocellular;¦Â-Catenin;immuno-histochemistry9¡¡¡¡Abstract:AIMToinvestigatethe¦Â-Cateninexpressionin

4、primaryhepatocellularcarcinomaanditsrelationshipwithtumordifferentiation£¬AFPlevel£¬invasion£¬metastasisandprognosis.METHODS¦Â-Cateninexpressionwasdetectedin63casesofprimaryhepatocellularcarcinomabyusingim-munohistochemicaltechnique£¨DABmethod£©.RESULTSExpressionof¦Â-Cateninin77.89%casesofprim

5、aryhepato-cellularcarcinomaand15%casesoflivercirrhosiswasstrongerthanthatinthesurroundingnormallivertissue.Thepositivityrateof¦Â-Cateninwashigherinpoorlydifferen-tiatedcarcinomagroupthanthatinwelldifferentiatedgroup£¨P<0.001£©.Thepositivityrateof¦Â-CateninwashigherinhighlevelAFPgroupthantha

6、tinlowlevelAFPgroup£¨P<0.001£©.Thepositivityrateof¦Â-Cateninwashigherinmetastaticcarcinomagroupthanthatinnonmetastaaticgroup£¨P<0.001£©.Thetwo-yearsurvivalratewaslowerin¦Â-Cateninpositivegroup£¨32.5%£©thanthatinnegativegroup£¨11.3%£¬P<0.05£©.CONCLUSIONStrongorpositiveex-pressionof¦Â-C

7、ateninisrelatedwithdifferentiation£¬AFPlev-elandmetastasisofprimaryhepatocellularcarcinoma.Theexpressionof¦Â-Cateninmighthaveprognosticvalue.¡¡¡¡0ÒýÑÔ¡¡¡¡Ô·¢ÐÔ¸Îϸ°û¸Î°©£¨HCC£©ÊÇÎÒ¹ú×î³£¼ûµÄ¶ñÐÔÖ×ÁöÖ®Ò»£¬Æä·¢²¡»úÖƺͷ¢²¡ÔÒòÖÁ½ñδÃ÷.ÒÑÓÐ