computational molecular biology an algorithmic approach - pavel a. pevzner

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2、fnewtechnologiesandtoolsformolecularbiology.TheMITPressSeriesonComputationalMolecularBiologyisintendedtoprovideauniqueandeffectivevenuefortherapidpublicationofmonographs,textbooks,editedcollections,referenceworks,andlecturenotesofthehighestquality.ComputationalModelin

3、gofGeneticandBiochemicalNetworks,editedbyJamesBowerandHamidBolouri,2000ComputationalMolecularBiology:AnAlgorithmicApproach,PavelPevzner,2000ComputationalMolecularBiologyAnAlgorithmicApproachPavelA.PevznerBibliothekTheMITPressCambridge,MassachusettsLondon,EnglandComput

4、ationalMolecularBiology©2000MassachusettsInstituteofTechnologyAllrightsreserved.Nopartofthisbookmaybereproducedinanyformbyanyelectronicormechanicalmethod(includingphotocopying,recording,orinforma-tionstorageandretrieval)withoutpermissioninwritingfromthepublisher.Print

5、edandboundintheUnitedStatesofAmerica.LibraryofCongressCataloging-in-PublicationDataPevzner,Pavel.Computationalmolecularbiology:analgorithmicapproach/PavelA.Pevzner.p.cm.—(Computationalmolecularbiology)Includesbibliographicalreferencesandindex.ISBN0-262-16197-4(he.:alk

6、.paper)1.Molecularbiology—Mathematicalmodels.2.DNAmicroarrays.3.Algorithms.I.Title.II.Computationalmolecularbiologyseries.QH506.P472000572.8—dc2100-032461Max-PIanck-InstitutfurInformatikBiblioihek&DokumenttrtionStuhlsatzcnhausweg85D-66V23SaarbriickeaTothememoryofmyfat

7、herContentsPrefacexiii1ComputationalGeneHunting11.1Introduction11.2GeneticMapping11.3PhysicalMapping51.4Sequencing81.5SimilaritySearch101.6GenePrediction121.7MutationAnalysis141.8ComparativeGenomics141.9Proteomics172RestrictionMapping192.1Introduction..192.2DoubleDige

8、stProblem212.3MultipleSolutionsoftheDoubleDigestProblem232.4AlternatingCyclesinColoredGraphs262.5TransformationsofAlternatin