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1、毕业论文(生物制药)（Graduationthesis(BiologicalPharmacy)）ningxiapolytechnicGraduationthesis(Design)Topic:theproductionprocessofOxytetracyclineStudentnameZhaoGangStudentnumber0701080221DepartmentofbiotechnologyandpharmacyProfessionalbiopharmaceuticalTutorZhaoXiaohongTwoyea
2、rs,April20thProcessforproducingoxytetracyclineChaoganPharmaceuticalSchool,NingxiaPolytechnic,Ningxia750001,Yinchuan,ChinaAbstract:Objective:Tosummarizetheproductionprocessofoxytetracycline.Methods:theextractionprocessistheremovalofoxytetracyclinepurifyingagentpro
3、teinofhighmolecularweightimpuritiesbyferrocyanide-zincsulfate,andthenusethe122-2resinwasfurtherpurifiedoxytetracyclinefiltrate,finallyadjustedtopH4.8bycrystallizationofoxytetracyclineproducts.Keywords:productiontechnology;oxytetracycline;zincsulfate-potassiumferr
4、ocyanide1oxytetracyclineoverviewAlsoknownasterramycinoxytetracyclineoroxytetracycline,Englishname(TerramycinOxytetracycline)isakindofantibiotics,antibacterialeffectsonavarietyofcocciandbacilli,alsohasinhibitoryeffectonparasiteRickettsiaandAmiba,usedinthetreatment
5、ofupperrespiratorytractinfection,gastrointestinaltractinfection,typhus,nowmainlyusedforanimalmedicineandfeedadditive.Oxytetracyclineisatypicaluseofbiologicalengineeringtechnologyproducts,theproductionprocessinvolvesseedcultivation,fermentation,extraction,filtrati
6、on,decoloration,crystallization,centrifugationanddryingandotherimportantunitoperationandengineeringconcepts,throughthefederalPharmaceutical(InnerMongolia)limitedliabilitycompanyinternshipproductionprocessofoxytetracycline,canimprovethepracticalabilitywiththecompr
7、ehensiveapplicationofknowledgelinktheory.1.1oxytetracyclineprofiles1.1.1nameandchemicalstructureformulaOxytetracyclineEnglishName:OXYtetracyclineChemicalname:(4S,4R,55S,R,6S,S12)-N-4-two-14,4methylamino,alpha,alpha5,5,6,11,12.Eight-5,6,10h,12,12,sixalphahydroxy-6
8、-methyl-1two,11-andfour-2-benzeneoxygengenerationofformamide.Molecularformula:C22H24N2O9,relativemolecularweight:460.581.1.2charactersandphysicalandchemicalpro
