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1、磷酸肌酸钠对行腹部手术老年冠心病患者心肌保护作用的评价14?论着?堑堡匿堂堡筮璺!鲞磷酸肌酸钠对行腹部手术老年冠心病患者保护作用的评价宣斐闰睿心肌摘要目的:观察磷酸肌酸钠对老年冠心病患者动脉血氧分压,心肌酶及心律失常的影响.方法:选择60例ASAII一11I级,行腹部手术的冠心病患者,随机分为对照组和实验组.实验组麻醉后使用磷酸肌酸钠,对照组使用生理盐水.两组分别在麻醉后,术后1h,术后2h及术毕时行血气分析观察动脉血氧分压的变化,于术后24h检测磷酸肌酸激酶同工酶(CPK—MB)和乳酸脱氢酶(L
2、DH)水平.记录围术期Ⅱ导联心电图室性心律失常的发生情况.结果:与对照组相比,实验纽术中lh,术中2h和术毕动脉血氧分压明显提高;术后24h心肌酶较术前均升高,但实验组上升幅度较对照组明显减少;围术期实验组室性心律失常的发生率为10%,明显低于对照组.结论磷酸肌酸钠能提高老年冠心病患者围术期的动脉血氧分压,心肌酶得到明显改善,减少室性心律失常的发生,具有明显的心肌保护作用.关键词磷酸肌酸钠;冠心病;动脉血氧分压;心肌酶;心律失常EvaluationofCreatinePhosphateSodiun
3、lonMyocardialProtectionEffectsofSenilePatientswithCoronaryHeartDiseaseXUANFei,YANRuiDepartmentofAnesthesiology,th—eAffiliatedTumorHospitalofXinjiangMedicalUniversity,Urumqi,)(inj.iang830011.ChinaAbstractObjectiveToinvestigatetheeffectsofcreatinephosph
4、atesodiumonarterialoxygenpartialpressure,cardiacenzymesandarrhythmiasinsenilepatientswithcoronaryheartdisease.MethodsSixtypa—tlentswithcoronaryheartdisease,ASAlI—llI,werescheduledforabdominalsurgery.A.1lthepatientswererandomlydividedintotwogroupsascon
5、trolgroupandstudygroup.Creafinephosphatesodiumandnormalsa-linewereintravenouslygiventostudygroupandcontrolgroupafteranesthesiarespectively.ArterialoxygenpartialpressureWasobservedafteranesthesia,1and2hourduringtheoperationandattheendofsurgeryth~.shart
6、erialbloodgasanalysisinthepatients.Isoenzymeofcreatinephosphokinase—MB(CPK—MB)andlactatedehydrogenase(LDH)levelsweretested24hourspost—operation.II—leadelectrocardiogramWel'~re—cordedtomonitorventriculararrhythmiaperioperatively.ResultsComparedwithcont
7、rolgroup,therewasasig-nificantincreaseinarterialoxygenpartialpressureofstudygroupIand2hourduringtheoperationandattheendofsurgery.Thecardiacenzymelevelsincreasedinallpatients,buttheamplitudesweresignificantlylowerinstudygroup.Theincidenceofperioperativ
8、eventriculararrhythmiainstudygroupwas10%.whichwassig-作者单位:830o11新疆乌鲁木齐新疆医科大学附属肿瘤医院麻醉科新疆医学2011年第4l卷15nificanflylowercomparedwithcontrolgroup.ConclusionsCreatinephosphatesodiunlcalleffectivelyincreasethearterialoxygenpartialpressure,decreasethec
